Studies reported an association between impaired hearing and vestibular function with the risk of dementia. This study investigated the association between Ménière’s disease (MD) and the risk of dementia using a nationwide cohort sample of data obtained from the South Korea National Health Insurance Service. The MD group (n = 496) included patients aged over 55 years and diagnosed between 2003 and 2006. The comparison group was selected using propensity score matching (n = 1984). Cox proportional hazards regression models were used to calculate incidence and hazard ratios for dementia events. The incidence of dementia was 14.3 per 1000 person–years in the MD group. After adjustment for certain variables, the incidence of dementia was higher in the MD group than in the comparison group (adjusted hazard ratio (HR) = 1.57, 95% confidence interval = 1.17–2.12). Subgroup analysis showed a significantly increased adjusted HR for developing Alzheimer’s disease (1.69, 95% confidence interval = 1.20–2.37) and vascular dementia (1.99, 95% confidence interval = 1.10–3.57) in the MD group. Patients with dementia experienced a higher frequency of MD episodes than those without dementia. Our findings suggest that late-onset MD is associated with an increased incidence of all-cause dementia, and it might be used as a basis for an earlier diagnosis of dementia.

Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal mucosa with an inflammatory or infectious etiology. Inflammatory bowel disease (IBD) causes chronic intestinal inflammation. Thus, both diseases share innate immune and epithelial barrier dysfunctions of the mucosa. However, the association between sinusitis and IBD is not well-known. We aimed to determine the association between CRS and the risk for IBDs, such as Crohn’s disease (CD) and ulcerative colitis (UC). In this long-term retrospective cohort study, 15,175 patients with CRS and 30,350 patients without CRS (comparison group) were enrolled after 1:2 propensity score matching. The incidence rates of CD and UC were 0.22 and 0.51 (1000 person-years), respectively. The adjusted hazard ratio (HR) for developing CD and UC in CRS patients was 1.01 (95% confidence interval (CI), 0.66–1.54) and 1.72 (95% CI, 1.26–2.36), respectively. Additionally, in the subgroup analysis using the CRS phenotype, the adjusted HRs of UC were significantly increased in patients with CRS without nasal polyps (adjusted HR = 1.71; 95% CI, 1.24–2.35), but not in those with CRS with nasal polyps. CRS without nasal polyps is associated with an increased incidence of UC but not CD. Therefore, clinicians should pay attention to the early detection of UC when treating patients with CRS without nasal polyps.

Heart rate variability (HRV) is the standard method for assessing autonomic nervous system (ANS) activity and is considered a surrogate marker for sympathetic overactivity in obstructive sleep apnea (OSA). Although HRV features are usually obtained from the short-term segment method, it is impossible to evaluate rapid dynamic changes in ANS activity. Herein, we propose the ultra-short-term analysis to detect the balance of ANS activity in patients with OSA. In 1021 OSA patients, 10 min HRV target datasets were extracted from polysomnographic data and analyzed by shifting the 2 min (ultra-short-term) and 5 min (short-term) segments. We detected frequency-domain parameters, including total power (Ln TP), very low frequency (Ln VLF), low frequency (Ln LF), and high frequency (Ln HF). We found that overall HRV feature alterations indicated sympathetic overactivity dependent on OSA severity, and that this was more pronounced in the ultra-short-term methodology. The apnea-hypopnea index, oxygen desaturation index, and Epworth sleepiness scale correlated with increased sympathetic activity and decreased parasympathetic activity, regardless of the methodology. The Bland-Altman plot analyses also showed a higher agreement of HRV features between the two methodologies. This study suggests that ultra-short-term HRV analysis may be a useful method for detecting alterations in ANS function in OSA patients.