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The prior-image-based linearization method exhibited better correction performance than conventional methods. Because the proposed method did not require time-consuming iterative reconstruction processes to obtain the optimal correction function, it can expedite the correction procedure and incorporate more high-order terms in the linearization correction function in comparison to the conventional methods.

Conventional intraoperative computed tomography (CT) has a long scan time, degrading the image quality. Its large size limits the position of a surgeon during surgery. Therefore, this study proposes a CT system comprising of eight carbon-nanotube (CNT)-based x-ray sources and 16 detector modules to solve these limitations. Gantry only requires 45° of rotation to acquire the whole projection, reducing the scan time to 1/8 compared to the full rotation. Moreover, the volume and scan time of the system can be significantly reduced using CNT sources with a small volume and short pulse width and placing a heavy and large high-voltage generator outside the gantry. We divided the proposed system into eight subsystems and sequentially devised a geometry calibration method for each subsystem. Accordingly, a calibration phantom consisting of four polytetrafluoroethylene beads, each with 15 mm diameter, was designed. The geometry calibration parameters were estimated by minimizing the difference between the measured bead projection and the forward projection of the formulated subsystem. By reflecting the estimated geometry calibration parameters, the projection data were obtained via rebinning to be used in the filtered-backprojection reconstruction. The proposed calibration and reconstruction methods were validated by computer simulations and real experiments. Additionally, the accuracy of the geometry calibration method was examined by computer simulation. Furthermore, we validated the improved quality of the reconstructed image through the mean-squared error (MSE), structure similarity (SSIM), and visual inspections for both the simulated and experimental data. The results show that the calibrated images, reconstructed by reflecting the calibration results, have smaller MSE and higher SSIM values than the uncalibrated images. The calibrated images were observed to have fewer artifacts than the uncalibrated images in visual inspection, demonstrating that the proposed calibration and reconstruction methods effectively reduce artifacts caused by geometry misalignments.

Several sinogram inpainting based metal artifact reduction (MAR) methods have been proposed to reduce metal artifact in CT imaging. The sinogram inpainting method treats metal trace regions as missing data and estimates the missing information. However, a general assumption with these methods is that data truncation does not occur and that all metal objects still reside within the field-of-view (FOV). These assumptions are usually violated when the FOV is smaller than the object. Thus, existing inpainting based MAR methods are not effective. In this paper, we propose a new MAR method to effectively reduce metal artifact in the presence of data truncation. The main principle of the proposed method involves using a newly synthesized sinogram instead of the originally measured sinogram. The initial reconstruction step involves obtaining a small FOV image with the truncation artifact removed. The final step is to conduct sinogram inpainting based MAR methods, i.e., linear and normalized MAR methods, on the synthesized sinogram from the previous step. The proposed method was verified for extended cardiac-torso simulations, clinical data, and experimental data, and its performance was quantitatively compared with those of previous methods (i.e., linear and normalized MAR methods directly applied to the originally measured sinogram data). The effectiveness of the proposed method was further demonstrated by reducing the residual metal artifact that were present in the reconstructed images obtained using the previous method.

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