Despite serious criticism, the boundaryless view of careers still heavily influences research. This article aims to do more than just challenge the claim that careers are becoming more boundaryless: our goal is to make clear that careers need to be thought of in alternative terms. To this end, we build on an analysis of academic careers to explain why regarding careers as either bounded or boundaryless is too simple and why more attention should be paid to the scripts that influence career choices. We draw from an empirical study carried out in two French universities that shows that promotion scripts operate under three conditions — credibility, legibility, and legitimacy of promotion models. We conclude that scripts are potentially very useful in understanding a wide range of careers.

Despite the existence of an extended armamentarium of effective synthetic drugs to treat HIV, there is a continuing need for new potent and affordable drugs. Given the successful history of natural product based drug discovery, a library of close to one thousand plant and fungal extracts was screened for antiretroviral activity. A dichloromethane extract of the aerial parts of Daphne gnidium exhibited strong antiretroviral activity and absence of cytotoxicity. With the aid of HPLC-based activity profiling, the antiviral activity could be tracked to four daphnane derivatives, namely, daphnetoxin (1), gnidicin (2), gniditrin (3), and excoecariatoxin (4). Detailed anti-HIV profiling revealed that the pure compounds were active against multidrug-resistant viruses irrespective of their cellular tropism. Mode of action studies that narrowed the site of activity to viral entry events suggested a direct interference with the expression of the two main HIV co-receptors, CCR5 and CXCR4, at the cell surface by daphnetoxin (1).

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Understanding change in higher education as bricolage: how academics engage in curriculum change Séverine LouvelTo cite this version: Séverine Louvel. Understanding change in higher education as bricolage: how academics engage in curriculum change. To cite this article Séverine Louvel. Understanding change in higher education as bricolage: how academics engage in curriculum change. Higher Education, Springer Verlag, 2013, 66 (6), pp.669-691. AbstractThe engagement of academics in organizational change in higher education institutions is generally understood as involving a wide range of behaviors, and previous studies have situated academics' actions at various points along a continuum between passivity and proactivity. This article complements this approach by asking how -rather than in which contexts -academics act as central agents for change in higher education. Rather than trying to assess their global level of proactivity in a given change situation, we aim at identifying the actions which show them behaving more or less strategically. We argue that the notion of 'bricolage' -widely used in organization theory -can be useful in this respect. Based on a qualitative study of the creation of 20 post-graduate nanotechnology programs on French university campuses, the article shows that academics participating in curriculum change engage in three distinct forms of bricolage. We suggest that the bricolage lens can identify two types of actions via which academics implement more or less pro-active strategiesidentifying a repertoire of resources, and assembling those resources -and so allows us to reflect more deeply on how these actions may demonstrate several forms of agency, as well as several different relationships with norms, in each organizational change situation.