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Aim: To examine whether tramadol wound infiltration decreased postoperative pain following cesarean section (CS) under general anesthesia or reduced the need for analgesics in the immediate postoperative period. Methods: In this double-blind, randomized trial, 60 women who underwent elective CS under general anesthesia were randomly allocated to one of two groups: placebo group (group P; n = 30) or tramadol group (group T; n = 30). Group P received 20 mL local wound infiltration with 0.9% saline solution, and group T received 20 mL local wound infiltration with tramadol 2 mg/mL within a 0.9% saline solution. The primary outcome, cumulative morphine consumption, and secondary outcomes including diclofenac requirement and postoperative pain were recorded. Results: Numerical rating scale score was lower in group T than in group P at 15 min postoperatively (P < 0.001). Patients in group T required significantly less morphine at all time intervals than those in group P (P < 0.001). There was no difference between groups in need for rescue analgesic dose (P 0.05). Conclusion: Wound infiltration with tramadol may be a useful technique in patients undergoing CS under general anesthesia to reduce postoperative pain and improve recovery.

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