ABSTRACTand prolonged mechanical pressure causes changes in the myelin sheath (28). Changes in intraneural microcirculation, impairment of axonal transport and alterations in vascular permeability have been detected. All of these cause edema formation and impairment of signal conduction (26).

Comorbidities in geriatric SCIWORA have severe effects on both etiology and prognosis. Furthermore, incontinence in SCIWORA is an essential condition that has not been addressed until now and may play a role in prognosis.

BackgroundChildren with juvenile idiopathic arthritis (JIA) are believed to have a lower cardiopulmonary capacity and functional ability. This means that they face more problems in performing daily activities compared with healthy children (1). Anaerobic capacity is important because most daily activities performed by children are anaerobic in nature (2). The association between anaerobic physical fitness and functional ability emphasized the importance of anaerobic physical fitness in children with JIA (3).ObjectivesThe purpose of this study is to examine whether children with JIA have lower cardiac capacity compared to healthy children and determine the clinical features that might be related to low aerobic capacity in children with JIA.Methods32 JIA patients and 11 healthy children aged between 6–16 years old participated in this study. The age, sex, height, weight, body mass index, disease duration, disease subtype, and medications of the participants were noted. Disease activity, functional disability and quality of life were measured with Disease Activity Score-28, Childhood Health Assessment Questionnaire and Pediatric Quality of Life scores, respectively. Knee or hip involvement in the patients was detected with physical examination. The ergospirometry stress test with bicycle was applied to all the participants to determine their cardiac capacity. The participants began the test with a load of half of their weight and a speed of 100 rpm (rapid per minute) and continued with a load that increased by 1 watt per 3 minutes. They were asked to pass the anaerobic threshold (respiratory exchange ratio). The VO2peak (the maximum volume of the oxygen consumed per minute) values were recorded to assess the aerobic capacity. The time passed after the thresholds (anaerobic capacity) and the total test time were also recorded to measure the whole (aerobic and anaerobic) cardiac capacity.ResultsThe averages of the cardiac capacity parameters (VO2peak level for the aerobic capacity and the total test time for the cardiac capacity) of the JIA group were significantly lower than those of the control group (p=0.00, p=0.00). There was no significant difference between the JIA (5.88 ±4.13 min) and the control groups (10.50±5.40 min) in terms of the time passed after the threshold (p=0.15). The investigations of the parameters that affect the VO2peak level revealed that women had a lower VO2peak level (p=0.02) compared to men and the participants with knee or hip involvement had a lower VO2peak level (p=0.01) compared to the ones who had no such a sign. Sex and CHAQ were identified as the most determinant factors on VO2peak level when the other probable risk factors were corrected (p=0.00, p=0.04).ConclusionsThis study shows that JIA patients have lower aerobic capacities. In JIA treatment, the lower limb involvement, physical functional state, and sex should be considered when targeting to increase the cardiopulmonary capacity of the patients In addition, customized treatment programs should be designed for the JIA patients....

No abstract

BackgroundNail ultrasonography (US) is a favourable visualisation method to evaluate the subunits of the nail. Little is known about the relation between the properties of nail structures and the clinical characteristics of patients with psoriatic arthritis (PsA).1 ObjectivesTo show the relationship between the clinical features and ultrasonographic evaluations of the nail in patients with PsA.MethodsPatients with PsA according to the CASPAR criteria were recruited into the study. All of the hand nails and toenails were examined by grayscale and power Doppler techniques. The relations between the characteristics of the patients and the sonographic findings of the nail structures were assessed. Concerning to patient characteristics, subtypes of PsA, gender, age, height, BMI, working status, smoking, PsA duration, psoriasis duration, history of dactylitis, history of uveitis, number of tender and swollen joints, Maastricht Ankylosing Spondylitis Enthesitis Score, CRP, disease activity, haemoglobin, sacroiliitis, inspectional nail involvement (INI), Nail Psoriasis Severity Index (NAPSI), PASI, HAQ, quality of life, and the biologic treatment were recorded. The nail plate thickness (NPT), number of nails with trilaminar irregularity (NTI), nail bed thickness (NBT), and the doppler activity score (DAS) were recorded as the sonographic nail findings. The Kruskal Wallis analysis, Spearman’s correlation, and Man Whitney U tests were used in statistical analysis. p<0.05 was accepted as significant.Results63 patients (756 nails) were evaluated. Among the PsA subtypes, 38% of patients were asymmetrical oligoarticular arthritis, 38% were symmetrical polyarthritis, 7.9% distal interphalangeal arthropathy, and 15.8% predominant spondylitis. All of the ultrasonographic nail parameters were independent of the PsA subtypes (p>0.05). The mean of NPT was higher in males and correlated with age, height, and the haemoglobin levels. The NTI score was higher in patients with INI and correlated with the NAPSI score. The mean of NBT was only correlated with the haemoglobin levels. The DAS was higher in workers and correlated with age and the NAPSI score. The other clinical parameters were not associated with the sonographic findings.Abstract THU0331 – Table 1Relationships between the patients’ characteristics and the ultrasonographic parameters*ConclusionsThe ultrasonographic findings of the nail structures were determined in PsA. These findings did not differ among the subtypes of the disease. Although the sonographic nail findings were not associated with the most of the clinical parameters; they had significant relations with some demographics, inspectional nail involvements, and haemoglobin levels in PsA.Reference[1] Acquitter M, Misery L, Saraux A, Bressollette L, Jousse-Joulin S. Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. Joint Bone Spine2017;84(6):703–707.Disclosure of InterestS. Acer: None declared, H. S. Baklacıoğlu: None declared, D. Erdem: None declared, ...