Background. It is uncertain if omega-3 polyunsaturated fatty acids are associated with increase in resting metabolic rate (RMR) in adults. Objective. The aim of the present study was to evaluate the overall effects of omega-3 on RMR. Methods. Both PubMed and Scopus libraries were searched up to April 2021. Study quality was assessed using the Jadad scale. Random- and fixed-effects models were utilized in order to obtain pooled estimates of omega-3 supplementation impacts on RMR, using weight mean difference (WMD). Results. Seven studies including a total of 245 participants were included. There was significantly higher FFM-adjusted RMR in the intervention group than the control group (WMD: 26.666 kcal/kg/day, 95% CI: 9.010 to 44.322, p = 0.003 ). Study quality showed that four of seven included studies were of high quality. However, there was no significant difference in results in the subgroup analysis according to the quality of studies. Subgroup analyses revealed significant changes for sex (for women: WMD = 151.793 kcal/day, 95% CI = 62.249 to 241.337, p = 0.001 ) and BMI (for BMI > 25: WMD = 82.208 kcal/day, 95% CI = 0.937 to 163.480, p = 0.047 ). Influence analysis indicated no outlier among inclusions. Conclusion. The current study depicted that omega-3 polyunsaturated acids can significantly increase RMR in adults. However, further assessments of omega-3 supplementation therapy are critical to monitor its long-term outcomes and potential clinical application.

backgrounds. type 2 diabetes mellitus (t2DM) is a common metabolic disease associated with pathophysiological changes in the neuromuscular system. the present study aimed to investigate the effects of a 6-week endurance training program on muscle strength, electrophysiological parameters, and functional activities in t2DM patients. Methods. the study period was divided into 6 weeks without training and 6 weeks with training. twelve t2DM patients participated in this study. During the training period, the same t2DM patients went through an endurance training program. the assessment process included measurement of muscle strength, surface electromyography (sEMG) recording, and functional tests. twelve healthy individuals were evaluated to compare their data with the t2DM patients. results. the results showed that the muscle strength and the amplitudes of the sEMG signals of t2DM patients were lower than those of the healthy subjects. the bioelectric activity of t2DM patients increased after six weeks of the endurance training program. the functional tests showed significant improvement after the endurance training program in t2DM patients, while no significant difference was observed between the t2DM and healthy subjects. conclusions. the short-term endurance-training program for lower limb muscles increased muscle strength and SEMG amplitudes of the knee extensor and flexor muscles and improved functional tests in t2DM patients, which may be attributed to neural adaptation after the endurance-training program. (clin Diabetol 2021; 10

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