No abstract

DHAA–Fe3O4@HA as a nano-carrier was synthesized for targeted sulfasalazine delivery in specific inflammatory joint tissues with improvement in RA disease.

N,N,N',N'‐tetrabromobenzene‐1,3‐disulfonamide and poly(N,N’‐dibromo‐N‐ethyl‐benzene‐1,3‐disulfonamide) were used as efficient catalysts for one‐pot synthesis of new quinazoline derivatives from various aldehydes, 2‐amino‐benzophenone, and ammonium acetate in good to excellent yields and new benzopyrano[2,3‐d]pyrimidine derivatives from salicylic aldehydes, various cyclic amines, and malononitrile in good to high yields.

In this study N,N,N 0 ,N 0 -tetrabromobenzene-1,3-disulfonamide was used as a reagent for the threecomponent one-pot synthesis of some novel 9-aryl-9H-2,4,5,7-tetramethyl-diuracilopyrans, which has not been published before, as well as 9-aryl-3,4,6,7-tetrahydro-2H-pyran-1,8(5H,9H)-diones in excellent yields. This is obtained from the condensation of aromatic and heterocyclic aldehydes and N,Ndimethylbarbituric acid or cyclohexane-1,3-diones in ethanol at room temperature.

A single-step, facile synthesis of new 1,8-naphthyridine derivatives was carried out at room temperature under mild conditions using a three-component condensation reaction of substituted 2-aminopyridines, malononitrile or methyl/ethyl cyanoacetate, and various aldehydes in the presence of N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide (TBBDA) or poly(N,N′-dibromo-N-ethylbenzene-1,3disulfonamide) (PBBS) as Lewis acid. A simple procedure, good to high yields, easy workup, and purification and reusability of the catalyst are significant advantages of this process.