Currently, the mood states are regarded as monopolar. This study tested in psychiatric subjects for the presence of five bipolar mood states after the influence of extreme response bias had been removed. The affective states hypothesized were: composed vs anxious, agreeable vs hostile, energetic vs fatigued, elated vs depressed, and clear-thinking vs confused. The sample of 303 cases included anxious, depressed and agoraphobic cases. Ratings of the 72 adjectives of the Profile of Mood States were intercorrelated. After extreme response bias score was partialled out the resulting correlations were analyzed by the method of principal components. The five factors isolated clearly support the bipolar nature of mood states postulated.

A meta-analysis of 22 studies of antidepressant outcome assessed the level of medication effects under conditions thought to be less subject to clinician bias than those in the typical double-blind drug trial. Studies were included only if, in addition to a newer antidepressant group, they also contained both standard antidepressant and placebo control groups. Effect sizes were quite modest and approximately one half to one quarter the size of those previously reported under more transparent conditions. Effect sizes that were based on clinician outcome ratings were significantly larger than those that were based on patient ratings. Patient ratings revealed no advantage for antidepressants beyond the placebo effect. Effect sizes were unrelated to sample sex ratios, patient age, inpatient or outpatient status, dosage level, and treatment duration. Findings highlight the fragility of the antidepressant effect.

Book Reviews Jung family. It is to our advantage that Miss Hannah has recorded information gleaned from thirty years of close contact with Jung, and which otherwise might have died with her. Thus his break with Freud, the indictment against him of Nazism, and his seemingly unorthodox private life are given new interpretations. Biographers of the future will, therefore, be most grateful for her personal reminiscences and penetrating portrayal of Jung's career. Meantime, her biography can be recommended as a welldocumented account of a man whose ideas have influenced, and continue to influence, us.

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Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments. Measures of palmar sweating and subjective anxiety showed that anticipation of speaking in public increased anxiety relative to baseline and prestress conditions, and performance of public speaking further increased anxiety. A dose-related anxiolytic effect of diazepam on subjective anxiety supported the model's clinical relevance. Moreover, the intensity of the subject's public speaking phobia predicted both degree of prestress anxiety relief from 10 mg diazepam and overall anxiety level, regardless of medication, throughout the experimental session. A measure of traditionalism predicted placebo and 5 mg diazepam response during prestress: As in previous clinical trials, high traditionalism scorers reported more relief from placebo, whereas low scorers showed more relief from diazepam.