Background Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). Methods Using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0-19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final point estimates are reported with 95% uncertainty intervals. Findings Globally, in 2017, there were 11•5 million (95% uncertainty interval 10•6-12•3) DALYs due to childhood cancer, 97•3% (97•3-97•3) of which were attributable to YLLs and 2•7% (2•7-2•7) of which were attributable to YLDs. Childhood cancer was the sixth leading cause of total cancer burden globally and the ninth leading cause of childhood disease burden globally. 82•2% (82•1-82•2) of global childhood cancer DALYs occurred in low, low-middle, or middle Socio-demographic Index locations, whereas 50•3% (50•3-50•3) of adult cancer DALYs occurred in these same locations. Cancers that are uncategorised in the current GBD framework comprised 26•5% (26•5-26•5) of global childhood cancer DALYs. Interpretation The GBD 2017 results call attention to the substantial burden of childhood cancer globally, which disproportionately affects populations in resource-limited settings. The use of DALY-based estimates is crucial in demonstrating that childhood cancer burden represents an important global cancer and child health concern. Funding Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities (ALSAC), and St. Baldrick's Foundation.

BackgroundSelf-esteem and behavioral consequences, which are due to external or internal locus of control, are effective on academic achievement of students.ObjectivesThe aim of this study was to determine the prediction of locus of control and self-esteem in academic achievement among the students.Materials and MethodsThis cross-sectional study was conducted on 300 college students in Kermanshah University of Medical Sciences in 2014. Data collection tools were in three sections: demographic, Rotter internal-external locus of control scale and Coopersmith self-esteem inventory. Data were analyzed using the SPSS software version 21.ResultsResults showed that 29.8% and 76.2% of the participants had internal locus of control, and high self-esteem, respectively. There was a significant correlation between self-esteem, locus of control and academic achievement of the students. Self-esteem accounted for 39.5% of the variation in academic achievement.ConclusionsIt seems that interventions to increase self-esteem among student can help improve academic achievement among them.

Background:Parents of children with leukemia should be receiving an extensive amount of information about the care of their child; the aim of this study was to determine the parents' information needs of children with leukemia. Methods: A cross-sectional study design was used to describe medical, physical, mental and lifestyle information needs among parents of children with leukemia. 209 parents of children diagnosed with leukemia in the west of Iran, during winter 2018, voluntarily participated in individual interviews. Data were analyzed by SPSS version 16 using t-test, One-way ANOVA and bivariate correlations statistical tests at 95% significant level. Results: The mean age of participants was 39.45 years [95% CI: 38.35, 40.55], ranged from 27 to 58 years. Participants achieved 55.6% score of information needs. There was a significant relationship between higher education level (P< 0.001), better economic status (P=0.008) and more family size member (P=0.003) with information needs. Conclusion: Findings suggest that parents of children with leukemia need the information to learn how to take care of their childhood and could be useful for guiding implementers to planning and implement effective programs to promotion information of parents towards children with cancer.

BackgroundFitness is a very important goal among young adults that may lead to eating disorders.ObjectivesThe aim of this study was to identify the factors influencing fitness intention based on the theory of planned behavior (TPB) and its relationship to eating attitudes.Materials and MethodsA cross-sectional study was conducted among 231 female college students during the winter of 2012. Participants were randomly selected in proportion to their distribution among the different faculties at Hamadan University of Medical Sciences. A structured questionnaire was applied for collecting data and data was analyzed by SPSS version 21 using a T-test, ANOVA, bivariate correlations, and linear regression at a 95% significant level.ResultsNearly 21.6% of the participants had abnormal eating attitudes. The TPB variables accounted for 40% of the variation in fitness intention. Bivariate correlations indicated a positive correlation between fitness intention and eating attitude (r = 0.417, P < 0.05).ConclusionsBased on our results, it seems that designing and implementing educational programs to reduce positive attitudes and encourage subjective norms toward fitness may be useful for preventing abnormal eating attitudes.

Background Respiratory distress syndrome (RDS) is a life-threatening pulmonary disorder which mainly related to the premature infants. This study was conducted to evaluate Continuous Positive Airway Pressure (CPAP) and High Flow Nasal Cannula (HFNC) intervention effectiveness among premature infants with RDS. Methods Overall, 60 preterm infants with RDS at Valiasr Hospital, Tehran, during 2018 in this randomized control trail participated as CPAP and HFNC groups’ treatment. CPAP group received the nose with a peep of 4-6 centimeters from birth and continued to improve respiratory distress and the need for oxygen (O2). HFNC group received hot and humid flowing 2 to 5 liters/min in nose cannula, until respiratory distress and O2 needing to be resolved. Short clinical outcomes were compared between two groups. Data were analyzed by SPSS version 16 using t-test and logistic regression statistical tests at 95% significant level. Results There were no significant differences in Pneumothorax, PDA, chronic lung disease, surfactant injection, tracheal intubation, death, NEC, number of full feeding days, duration of hospitalization, and number of oxygen therapy days between the both CPAP and HFNC groups. Conclusions CPAP and HFNC techniques have the same efficacy in confronting RDS in neonates and there is no difference between the two techniques in terms of in-hospital clinical outcomes. However, considering the same efficacy of two methods and less invasive of HFNC compared with CPAP, we concluded this method can be recommended for the improvement of respiratory distress in newborns. Trial Registration Iranian Registry of Clinical Trials identifier IRCT20190623043988N1 Registered 2019-07-05.