The surface of Fe 3 O 4 magnetic nanoparticles (MNPs) was modified by chloropropylsilane and histidine. The imidazole group of prepared Fe 3 O 4 @Propylsilane@Histidine MNPs converted to imidazolium hydrogen sulfate group and Fe 3 O 4 @Propylsilane@Histidine [HSO 4 -] as a novel environmentally friendly ionic liquid/ magnetite nanoparticle was prepared, successfully. FT-IR, XRD, SEM and TEM instruments was used to identifiy the histidine ionic liquids/magnetite nanoparticles (HILMNPs). The catalytic activity of synthesized HILMNPs was appraised for the synthesis of 9-aryl-1,8dioxooctahydroxanthene and spiro[indoline-3,9′-xanthene]trione derivatives.The activity of HILMNPs was much better than the other reported heterogeneous and homogeneous catalysts. Furthermore, the prepared catalyst could be separated from the reaction mixture and reused four times without any significant loss in its activity.

A simple, economical, three-component, and one-pot synthesis of novels spiro [indoline-3,5′-pyrido[2,3-d]pyrimidine] derivatives by condensation of dimethyl acetylene dicarboxylate, isatin derivatives, and 6-amino-1,3dimethyluracil in presence of Fe 3 O 4 @Propylsilane@Histidine[HSO 4− ] as an impressive catalyst via reflux and ultrasound procedure is described. The results show that ultrasound method has several advantages such as milder condition, shorter reaction time, and higher reaction yield.