Stroke is a major cause of disability and the third leading cause of mortality in human. In recent decades, the incidence of stroke has significantly increased especially in developing countries. Approximately 20% of patients die within one month after the stroke. Moreover, patients who live more than six months are dependent others for their daily work. They have complications such as paralysis of a body part, impairment of memory, thinking, talking and moving. Due to the complex pathological process of ischemia, using a single agent in the treatment of ischemia does not seem ideal. Thus, studies for finding compounds and effective methods are growing. In recent years, attention to medicinal plants as a potential source in treatment of ischemia-reperfusion has increased. Here, association between medicinal plants with reduction of cerebral ischemia was reviewed. At the end, it was determined potential of medicinal plants in abrogation of cerebral ischemia through several different pathways. Thus, they can be a new source for production of medications against cerebral ischemia.

Curcumin regulates cellular signaling pathway related to cancer growth, inflammation and apoptosis and due to biological activities can be target DNA, RNA and enzymes. In addition, curcumin has inhibitory effect against MARK, P53, β-catenin and AKT. It can be consider as a promising agent to treat many diseases but it is important that should be acceptably carried out cellular targeting with curcumin. Here, we reviewed beneficial effects of curcumin in treatment of diseases. Our review study was confirmed that curcumin has potential effect in diseases treatment but there is a dire need for increase of its bioavailability in order to promotion of its efficacy. We suggest that should be design the methods for increase of cellular targeting by curcumin in further studies.