Highlights The incidence of VTE among hospitalised COVID-19 patients was high, particularly among patients in ICU. Anticoagulation was not associated with an increased risk of mortality in hospitalised COVID-19 patients. Clinical trials are urgently needed to evaluate the roles of prophylactic and therapeutic anticoagulation in COVID-19.

Three new alkaloids, 15b-dehydro-5- N-acetylardeemin ( 3), 10-phenyl-[12]-cytochalasins Z16 ( 6) and Z17 ( 7), were characterized from the liquid culture of the endophytic fungus ASPERGILLUS TERREUS IFB-E030 along with six known derivatives, 5- N-acetylardeemin ( 1), 15b- β-hydroxyl-5- N-acetylardeemin ( 2), cytochalasin E ( 4), rosellichalasin ( 5), cytochalasins Z11 ( 8), and Z13 ( 9). The structures of the new metabolites were established mainly by a combination of their 1D- and 2D-NMR spectra, single crystal X-ray diffraction, and the modified Mosher reaction. Biological assays indicated that cytochalasin Z17 ( 7) had moderate cytotoxicity against human nasopharyngeal epidermoid tumor KB cell line with an IC (50) value of 26.2 µM.

Metal selenides have attracted increased attention as promising electrode materials for electrochemical energy storage and conversion systems including metal-ion batteries and water splitting. However, their practical application is greatly hindered by collapse of the microstructure, thus leading to performance fading. Tuning the structure at nanoscale of these materials is an effective strategy to address the issue. Herein, we craft MoSe with hierarchical hollow structures via a facile bubble-assisted solvothermal method. The temperature-related variations of the hollow interiors are studied, which can be presented as solid, yolk-shell, and hollow spheres, respectively. Under the simultaneous action of the distinctive hollow structures and interconnections among the nanosheets, more intimate contacts between MoSe and electrolyte can be achieved, thereby leading to superior electrochemical properties. Consequently, the MoSe hollow nanospheres prepared under optimum conditions exhibit optimal electrochemical activities, which hold an initial specific capacity of 1287 mA h g and maintain great capacity even after 100 cycles as anode for Li-ion battery. Moreover, the Tafel slope of 58.9 mV dec for hydrogen evolution reaction is also attained.

An ew protocol for the construction of ac rucial bicyclic lactone of prostaglandins using as tereocontrolled organocatalytic Baeyer-Villiger (B-V) oxidation was developed. The key B-V oxidation of ar acemic cyclobutanone derivative with aqueous hydrogen peroxideh as enabled an early-stage construction of ab icyclic lactone skeleton in high enantiomeric excess (up to 95 %). The generated bicyclic lactone is fully primed with two desired stereocenters and enabled the synthesis of the entire family of prostaglandins according to Corey'sr oute.F urthermore,t he reactivity and enantioselectivity of B-V oxidation of racemic bicyclic cyclobutanones were evaluated and 90-99 %e ew as obtained, representing one of the most efficient routes to chiral lactones. This study further facilitates the synthesis of prostaglandins and chiral lactone-containing natural products to promote drug discovery.