Polycystic ovary syndrome (PCOS) is a frequently encountered problem affecting 6-11% women of reproductive age.1 Purpose of the study was to determine whether serum AMH level can be used to diagnose PCOS. Methods: It was a cross sectional study conducted among 55 sub-fertile women of reproductive age (18-35 year) in a tertiary level hospital during the period of January 2018 to December 2018. The study subjects were divided into group I (PCOS patient with subfertility by Rotterdam Criteria 2003) and group II (non PCOS subfertile patients of reproductive age). Menstrual history, obstetrical history, physical examination, clinical assessment of androgenesis, ovarian ultrasound assessment and level of AMH, FSH, LH were collected. Result: Twenty five PCOS & 30 non PCOS sub-fertile patients were recruited. Mean age in PCOS & non PCOS were 25.24±4.03 years and 27.8±5.01 years respectively. The mean serum AMH in PCOS was 11.03±3.78 ng/ml and in non PCOS was 3.93±1.92 ng/ml, their difference was statistically significant. Conclusion: AMH can be used as a diagnostic aid for PCOS. J Shaheed Suhrawardy Med Coll, December 2019, Vol.11(2); 142-146

Subfertility, a global health issue is defined as the failure in pregnancy after one year of unprotected intercourse. It affects approximately 10%-15% of the couple in developed country1. It is not merely a health problem but also a matter causing social instability, marital disharmony and many disgraceful conditions. Regarding causes of subfertility, female factor, male factor, combined male and female factors and sometimes unexplained factors are responsible. Objective: The aim of the study was to find out the etiological factors and the patterns of subfertility among the couples attending the infertility clinic and outpatient department (OPD) of Kurmitola General Hospital of Bangladesh. Methods : This cross-sectional study was done at the OPD and infertility clinic of Kurmitola General Hospital during the period of January 2019 to- December 2019. Total 140 couples with necessary investigations were interviewed by structured questionnaire. Data analysis done under SPSS method. Result : In this study total number of 140 couples were studied. The frequency of primary and secondary subfertility was 55% and 45% respectively. Among 140 couples mean age of female was 32.6 year and mean age of male was 36.4 year. The mean duration of the subfertility among the couples was 7 year. Concerning the contribution of male and female factor among 140 couples, female factor was responsible in 55% case and male factor was responsible in 20% cases, 10% had combined male and female factor and in 15% couple causes of subfertility was unexplained. Regarding the etiology of subfertility among women, different factors included. Polycystic ovarian syndrome (PCOS) 46.15%, tubal factor 31.86%, endometriosis 8.79%, among hormonal disorder hypothyroidism was responsible in 5.49% and hyperprolactinemia in 2.19 % cases, and ovarian cause like poor ovarian reserve was responsible in 4.39% cases and uterine factor was responsible in 1.09% cases. To detect the male factors of subfertility semen analysis report was done., among male partner 69.04% had oligospermia, 16.66% show asthenospermia, another 9.52% show teratospermia. Azoospermia was detected in 4.76% cases. Conclusion: Bangladesh is a developing country where population burden is a big concern. On the other hand, reproduction is a basic human right. As the subfertility leads to physical, psychological and social problems so government needs to take care of this subfertility issue. This study gives us the idea of the needs and further demands of the services in our country to identify social cultural and economic factors associated with subfertility and interventions needed to overcome the current situation. Sir Salimullah Med Coll J 2021; 29(2): 136-140

Background: Adjunctive therapies to have a baby and widespread perception is that dietary supplementation such as myo-inositol are associated with only benefit, not with harm in case of PCOS women. The use of 2×1000mg myo-inositol +2×200microgram folic acid per day is a safe and promising tool in the effective improvement of symptoms and infertility for patients with a PCOS. Objectives: To evaluate the effectiveness and safety of oral supplementation of inositol for reproductive outcomes among subfertile women with PCOS who are trying to conceive. Materials and methods: Using questionnaire an observational study was performed in ShSMCH of outdoor infertility clinic and routine clinical practiced. In this observational study Thirtyfive PCOS women of childbearing age with oligo or amenorrhea were enrolled in the study. Ovulatory disorder due to PCOS was apparently the only cause of infertility; no tubal defect or deficiency of male semen parameters was found. Myo-inositol combined with folic acid 2g twice a day was administered continuously. During an observation period of 6 months from July,2018 to December, 2018, ovulatory activity was monitored with ultrasound scan and hormone profile and the number of spontaneous menstrual cycles and eventually pregnancies were assessed. Results: Twenty eight out of 35 (80%) patients restored their spontaneous menstrual cycle during treatment. A total of 10 singleton pregnancies (28.5% of patients) were obtained. Nine clinical pregnancies were assessed with fetal heart beat at USG scan. One pregnancies evolved in spontaneous abortion. Conclusion: Myo-inositol is a simple and safe treatment that is capable of restoring spontaneous ovarian activity and consequently fertility in most patients with PCOS. This therapy did not cause multiple pregnancy. J Shaheed Suhrawardy Med Coll, December 2019, Vol.11(2); 115-118