Background: Traumatic brain injury (TBI) is an impairment with high prevalence amongst the pediatric population. Central nervous system (CNS) regulates food intake and each region of the brain can be responsible for appetite control network. It seems that TBI might affect appetite control system which could result in overeating or reduced food intake. Hence, the aim of this study was to determine, if there is a relationship between daily energy intake and satiety related hormones with computerized tomography scan (CT scan) findings in children with mild to moderate TBI.Methods: In this cross sectional study, 50 pediatrics with mild to moderate TBI were recruited and the following steps were performed for each patient: Completing the demographic information (age, gender, medical disorders, etc.), dietary intake assessment, taking blood samples for biochemical evaluations, and evaluating psychological disorders using the “Rutter Children Behavior Questionnaire”. The patient's CT scan was also used to determine the main area of brain injury. Results: The results showed that in comparison with the Reference Dietary Allowance (RDA) values, calorie intake was inadequate in 32% of the patients, while 32% had excess calorie intake. Comparison of the mean daily energy intake and serum levels of satiety hormones in different categorical CT scan findings showed that there was a significant relationship between energy intake and the site of injury. Post- hoc analysis showed that energy intake in patients with temporal lobe injury was significantly higher than in patients with frontal lobe injury or injuries to other sites of the brain. The results also showed that mean serum Ghrelin and Orexin levels in patients with temporal lobe injury were higher than patients with frontal lobe injury but no significant relationship was found regarding leptin and site of injury. Moreover, it was shown that children with frontal lobe injury had significantly more behavioral disorders.Conclusions: It seems that frontal lobe injuries might be associated with anorexia while temporal lobe injury can be associated with increased food intake. Future studies are recommended to determine, if there is a relationship between satiety related hormones with other site of injury in TBI patients.