Objective: To determine the effect of amblyopia patching therapy on visual outcome in young and adults at 6th and 12th week. Study Design: Quasi-experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology Rawalpindi, Pakistan, from Sep 2018 to Jan 2020. Methodology: Out of 110, follow up was successfully completed by 91 eyes. Subjects were divided into young and adult based on age. Age ranging from 5-12 years included in the young group and adult group included those ranging from 13-20 years. Anisometropic amblyopia was considered. Amblyopia due to any other disease were excluded. Subjects were advised patching therapy daily for 4 hours in the affected eye. Follow up was 3 weekly for 12 weeks and the effect of patching therapy was assessed by visual improvement. Statistical analysis was done with SPSS version 21. Result: Out of 91 eyes with amblyopia, 51 (56.6%) were included in the young group while 40 (43.4%) were included in the adult group. In the young group, visual improvement was seen in 40 (78.4%) while in the adult group 24 (60%) showed improvement in vision. Mean visual improvement in young was 1.66 ± 1.099 while 1.03 ± 0.944 in the adult group. Maximum visual improvement in both groups was seen till the 6th week of patching. Conclusion: Patching therapy is effective even at later ages too. However, continuing patching for more than 6 weeks doesn’t show much improvement in vision.

Objective: To assess the efficacy of oral Doxycycline in reducing the size of pterygium lesions in a Pakistani population Study Design: Quasi-experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi, from Sep 2018 and May 2019. Methodology: Sixty patients above 20 years of age were enrolled in the study. Oral Doxycycline 200m/day was given for thirty consecutive days. Photographs of the lesions were taken at the time of recruitment and at the end of the study for assessment of pterygium size. Difference between pre-treatment and post-treatment size was analysed and comparison was made with age, gender and initial lesion size. Results: Twenty-two females and thirty-eight males were examined. The mean age of the participants was 48.8 ± 13.8 years. The mean size of the pterygium lesions before commencing the treatment was 12.24 ± 6.28 mm2. The mean size of the lesions after the treatment was 11.24 ± 5.39 mm2. The mean difference size was 1.00 ± 1.62 mm2 (p <0.001). The relative change in size (i.e. post-treatment size divided by pre-treatment size) was 0.94 ± 0.09 which was found to be statistically significant (p<0.001). There was correlation between larger initial lesion size and greater relative reduction in size (r = -0.42, p = 0.001). Conclusion: The change in the size of pterygium lesions produced by Doxycycline was found to be statistically significant but was not deemed clinically significant. Therefore, oral Doxycycline is not recommended for the treatment of pterygium in our population.