Peningkatan jumlah pasien COVID-19 menjadi perhatian utama para tenaga kesehatan, termasuk apoteker. Penelitian ini bertujuan untuk mengetahui bagaimana pengetahuan, kesadaran, dan praktik apoteker komunitas di beberapa wilayah di  Indonesia terhadap wabah COVID-19. Penelitian ini didesain secara cross-sectional dengan pengambilan data dilakukan secara daring. Data diambil melalui survei menggunakan kuesioner yang terdiri dari delapan pertanyaan mengenai demografi dan 32 pertanyaan mengenai pengetahuan, kesadaran, dan praktik apoteker tentang pandemi COVID-19. Kuesioner disebarkan kepada apoteker yang memiliki Surat Ijin Praktik Apoteker  (SIPA) aktif dan bekerja di komunitas. Sebanyak 116 apoteker di komunitas berpartisipasi pada penelitian ini. Hasil penelitian menunjukkan bahwa 99,14% (n=115) responden memiliki pengetahuan yang baik mengenai COVID-19 dan sebanyak 68,10% (n=79) responden memiliki kesadaran yang baik terkait COVID-19. Meskipun sebagian besar reponden menunjukkan  nilai skor pengetahuan dan kesadaran yang tinggi, hanya 62,93% (n=73) responden yang selalu mempraktikkan protokol kesehatan saat memberikan layanan kesehatan di masyarakat. Mayoritas apoteker komunitas telah menunjukkan pengetahuan dan kesadaran yang tinggi terhadap wabah COVID-19. Diperlukan peningkatan implementasi protokol kesehatan di apotek sebagai upaya pencegahan penyebaran COVID-19.

Background: Patients with cardiovascular diseases (CVD) are vulnerable to experiencing drug-drug interactions (DDIs). DDIs are a concern among patients receiving multiple drug regimens but they are also an avoidable cause of adverse drug reactions. The study of potential DDIs (pDDIs) would make it easier for the healthcare provider to deliver better patient care and mitigate pDDIs incidence. Objective: This study aimed to assess the frequency, severity level and risk factors associated with pDDIs among medications used to treat hypertensive ambulatory patients in Universitas Airlangga hospital. Methods: A retrospective observational study was carried out from electronic prescriptions received by hypertensive patients in March 2021. Data collection includes demographic data, the profile of antihypertensive drug use, and pDDIs. pDDIs were identified by severity using Lexicomp Drug Interaction Checker (Application). Univariate logistic regression analysis was used to find associated factors of major pDDIs. A p-value less than 0.05 (≤ 0.05) was considered statistically significant. Results: From 704 patients, 53.98% women and 46.02% men, 89.06% (n = 627) patients had minor to major pDDIs; 1354 pDDIs were identified, 89.4% (n = 1,210) were moderate and 9.8% (n = 133) were major class. Multiple antihypertensive drug regimens had significance associated with the major pDDIs occurrence. Conclusion: We found a high prevalence of pDDIs among hypertensive patients. The majority of pDDIs were of moderate severity. Multiple antihypertensive drug regimens were associated factors in the presence of major pDDIs.