No abstract

The relative activity of acetyl CoA hydrolase and acetyl CoA synthetase was investigated in mitochondria from bovine liver, heart, kidney, lung, brain, mammary gland, and skeletal muscle. Acetyl CoA hydrolase activity is high in liver, mammary gland, kidney, and brain. The enzyme is much less active in heart, lung, and skeletal muscle. Hydrolase activity relative to synthetase activity is high in liver and brain. The synthetase activity is much greater than the hydrolase activity in the other tissues. The intracellular localization of acetyl CoA synthetase was determined in bovine heart, kidney, mam-