Background: Bladder cancer is one of the most common cancers worldwide and its incidence and mortality rates vary globally due to genetic variation, population age and exposure to risk factors. In the present study we aim to report national and subnational incidence of bladder cancer in Iran between 2003 and 2015.Methods: This population-based study investigate the age-standardized incidence rates (ASRs) of bladder cancer between 2003 and 2015 in Iran and its 32 provinces using last updated data from national cancer registry system of non-communicable disease center of Iran Ministry of Health, and Medical Education. Results: ASR of bladder cancer increased from 8.35 in 2003 to 13.57 in 2015 in men. ASR of bladder cancer also showed a mild increase in females, 2.12 in 2003 versus 2.86 in 2015.Conclusion: In conclusion, we observed an increasing trend of bladder cancer incidence in Iran, highlighting the disease as a potentially major health problem in the future. Therefore, it is necessary for health organizations to implement effective educational, preventive and therapeutic programs in the country to prevent further increase of disease burden.

Development of penile metastasis in patients with colorectal cancer is a rare condition and is associated with widespread metastasis and poor outcomes. We report a Case of metastasis to the penis with unique magnetic resonance imaging feature.

overall MMR status when age 50 was used as a hypothetical testing threshold. After correcting for tumour grade as a confounding variable it was shown that MLH1 and PMS2 expression were negatively correlated with increasing age while MSH6 expression was positively correlated with increasing age at diagnosis (figures 1 and 2). Conclusion There is no statistically significant difference in overall immunohistochemical MMR status when using the age of 50 as a threshold for tumour analysis. Such a threshold would have missed 82.3% of cases with tumoral MMR deficiency and should not be included in lab protocols for EEC IHC analysis. Reflex testing of all EEC cases is highly advised as IHC testing is no longer solely about diagnosis of Lynch syndrome. Prospective evidence is required to clarify the role IHC scoring and semi-quantitative analysis should play in MMR status interpretation and patient management especially in the ever-evolving field of targeted therapeutics. Disclosures This study was self-financed. Authors declare they have no conflict of interest, financial or otherwise.

Ewing sarcoma (ES) is an entity which belongs to a spectrum of neoplastic diseases called the Ewing sarcoma family of tumors (EFT). EFTs of the kidney represent less than 1% of all renal tumors. Herein, we presented a case of primary renal ES with tumor thrombosis up to vena cava who underwent radical nephrectomy and IVC tumor thrombectomy followed by adjuvant chemotherapy. Histopathology showed that the tumor composed of small uniform, dark, round cells arranged in sheets, and rosettoid pattern. The diagnosis of ESFT was confirmed by detecting EWS/FLI-1 fusion gene using reverse transcription polymerase chain reaction (RT-PCR).