Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional vaccinations may have low immunogenicity and, in most situations, only provide partial protection. A new class of nanoparticle-based vaccinations has shown considerable promise in addressing the majority of the shortcomings of traditional and subunit vaccines. This is due to recent breakthroughs in chemical and biological engineering, which allow for the exact regulation of nanoparticle size, shape, functionality, and surface characteristics, resulting in improved antigen presentation and robust immunogenicity. A blend of physicochemical, immunological, and toxicological experiments can be used to accurately characterize nanovaccines. This narrative review will provide an overview of the current scenario of the nanovaccine.

Morus alba Linn. is a plant with varieties of phytochemicals and commonly known as Mulberry tree or Nuni (in Assamese). Mulberry is a perennial and woody plant, belongs to the family Moraceae consider as a native plant of China. In Assam, the leaves of mulberry tree are out most important in horticulture department for feeding purpose. A literature survey was done out by using key words such as Morus alba, or mulberry tree or phytoconstituents, or pharmacological activities, or ethnobotany on the search engine namely Scopus, Web of Science, Google Scholars, PubMed. The purpose of this article is to forward a solid review about the plant profile, method of extraction, phytochemicals constituents and pharmacological activities in reference to SARS-CoV-2. All the parts of Morus alba are phytochemically rich but highest number can be found in fruits and leaves. Fruits of Morus alba contains various class of phytochemicals such as alkaloids, anthocyanins, stillbenoids, flavones. Owing to presence of this compounds, it exhibits various pharmacological. Its leaves, fruits and root bark containing flavonoids, anthocyanins, alkaloids and stilbenoids, possess various pharmacological properties. Resveratrol is one of the most important compounds found in M. alba which possess SARS-CoV-2 inhibiting potential. Still there are some gaps remain in exploring whole plants parts and successive studies of toxicity.

Medicinal plants or medicinal herbs possess therapeutic properties or exert beneficial pharmacological effects on human. From time immemorial, people have been using various medicinal plants without even knowing their phytochemistry and pharmacological properties as a medicine for treating numerous ailments. As technology developed and upgraded, people used to screen out various phytoconstituents as well as evaluate their basic pharmacological properties. Tinospora cordifolia is a medicinal herb which is commonly known as Giloy belong to family menispermaceae. It can also be found in places like Africa, China, South-East Asia, Indo-Malaya region and Australia. Traditionally, people use this herb as prominent food materials due to their higher nutraceutical value and various healing properties. For phytochemical investigation, extraction of whole plant is preferable whereas most of the phytochemical are found to be present in leaves. Various potent phytochemicals are found in this herb such as tinosponone, tinocordiside, tinosporaside, cordifoliside, β-sitosterol, mekisterone A, etc. which are belong to class of alkaloids, sesquiterpenoids, glycosides, steroids, volatile oil, etc. Owing to the presence of these potent compounds, it exhibits wide range of large number of pharmacological activities such as antiviral, antibacterial, antifungal, antioxidant, antidiabetic, anticancer activities, etc. In past two years, SARS-CoV-2 infections has taken life of millions of people across the globe and there were no any vaccine or proper antiviral medicine available to defend this deadly pandemic, hence people were mostly relying on herbal plant therapy. Giloy is one such magical herb which exhibit healing properties in SARS-CoV-2 infected patients. Moreover, in-silico studies have been carried out to determine the binding affinity as well as inhibiting potential of various phytoconstituents of giloy. In this review work, we compiled all the updated information about T. cordifolia as well as emphasizing more on SARS-CoV-2 inhibiting potential.

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