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The purpose of this study was to produce intelligent pectin‐based superabsorbent polymers (SAP) to be used as pH‐ and thermosensitive carriers for the controlled delivery of non‐steroidal anti‐inflammatory drugs (NSAIDs). The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FT‐IR) and scanning electron microscopy (SEM).The effects of pH, ionic strength, temperature, porosity, particle size and levels of loaded drug on drug release profile in various surrounding media were investigated. Each sample was well characterized through swelling studies. The molecular weight between crosslinks $\displaystyle (\overline {{\tf="PS_HENI"M}}_C) $, crosslinking density (ve) polymer–solvent interaction parameter (χ), and the shear modulus of the superabsorbents (G) were calculated. The results revealed that the release profiles of IBU from the superabsorbent polymer were low (lower than 14%) in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the initial drug content (more than 79%) was released in simulated intestinal fluid (SIF, pH 7.4) within 6 h after changing media. Overall the results demonstrated that biodegradable superabsorbents could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates for an orally administrated drug delivery system.

Novel types of highly swelling hydrogels were prepared by grafting crosslinked polyacrylamide-copoly-2-acrylamido-2-methylpropane sulfonic acid (PAAmco-PAMPS) chains onto sodium alginate (Na-Alg) through a free radical polymerization method. The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FTIR). The controlled release behavior of diclofenac sodium (DS) from superabsorbent polymer was factinvestigated, and shown that the release profiles of DS from superabsorbent polymer were slow in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the initial drug content was released in simulated intestinal fluid (SIF, pH 7.4) within 21 h after changing media. Overall the results demonstrated that biodegradable superabsorbent could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates as an orally administrated drug delivery system.

The purpose of this study was to produce an intelligent superabsorbent polymer (SAP) to be used as a pH sensitive matrix for the controlled delivery of drugs. Novel types of highly swelling SAPs were prepared by grafting crosslinked acrylic acid‐co‐acrylamide (AA‐co‐AAm) chains onto pectin by free‐radical polymerization. The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FT‐IR) and scanning electron microscopy (SEM). The controlled release behavior of ibuprofen (IBU) from the superabsorbent polymer was investigated. SAP structural‐property relationships that affect its controlled release behavior were determined. Analysis of the results indicated that it is possible to optimize ibuprofen (IBU) controlled release by adjusting the SAP composition and the crosslinking degree of the copolymer. The results revealed that the release profiles of IBU from the superabsorbent polymer were slow (lower than 2%) in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the initial drug content (more than 84%) was released in simulated intestinal fluid (SIF, pH 7.4) within 85 h after changing media. Overall the results demonstrated that biodegradable superabsorbents could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates as an orally administrated drug delivery system.