Lumpy skin disease (LSD) is a viral disease that affects farm animals including water buffalo. It is caused by the contagious LSD virus, a member of the Poxiviridae family's Capripox genus. Skin sores are thought to be the most common site of infection since the virus may live for lengthy periods in lesions or scabs. The first clinical indications of LSD were described in Zambia, in 1929. Pakistan has also been afflicted by LSD, with a high number of animals infected at many cattle ranches in Karachi, 190,000 cases of LSD have been reported nationwide, with greater than 7500 deaths attributable to the illness. LSD has a huge influence on Pakistan's economic status, resulting in the loss of cattle and a decrease in milk output. The Ministry of Research and National Food Safety in Pakistan has formed a working group to create a framework for controlling the spread of LSD in cattle and buffalo. Official and private veterinarians, both field and slaughterhouse, veterinary students, farmers, cattle merchants, cattle truck drivers, and artificial inseminators should all participate in awareness efforts.

The world’s ecosystem is severely affected by the increase in the rate of soil erosion and sediment transport in the built environment and agricultural lands. Land use land cover changes (LULCC) are considered as the most significant cause of sediment transport. This study aims to estimate the effect of LULCC on soil erosion potential in the past 20 years (2000–2020) by using Revised Universal Soil Loss Equation (RUSLE) model based on Geographic Information System (GIS). Different factors were analyzed to study the effect of each factor including R factor, K factor, LS factor, and land cover factor on the erosion process. Maps generated in the study show the changes in the severity of soil loss in the Chitral district of Pakistan. It was found out that 4% of the area was under very high erosion risk in the year 2000 which increased to 8% in the year 2020. An increase in agricultural land (4%) was observed in the last 20 years which shows that human activities largely affected the study area. The outcomes of this study will help the stakeholders and regulatory decision makers to control deforestation and take other necessary actions to minimize the rate of soil erosion. Such an efficient planning will also be helpful to reduce the sedimentation in the reservoir of hydraulic dam(s) constructed on Chitral river, which drains through this watershed.

Thymus is a ductless, highly organized, bilobed encapsulated gland of the lymphoid organs that contributes in thymopoiesis. Thymus plays an important function in the assortment, progress and profusion of T cells. The mature subsets of thymus dependent lymphocytes linked with the thymic epithelial and other cells developed the microstructure that protect the body from the harmful foreign microorganism. Most of the thymic lobular areas experienced the parenchymal cells hypoplasia, undergone infiltration of stromal FCT and experienced thymic atrophy with age progression. As the host gets adult, the regression of the thymus and the thymopoiesis occurs, which ultimately boost the vulnerable situations of the host and open a gateway to autoimmune diseases. Since past decades, scientists are intensely investigated to develop some tactics for the improvements of the thymus performance including T-cell regeneration and maturation with age progression. This unique organ is continuously altered morphologically with age and disease; however, this microarchitectural alteration and its possible modulations is not yet clear. Therefore, the main purpose of this chapter is to highlight the microstructural compartments and physiological modification of the thymus with age. Also, the chapter is suggesting the possible alternative ways to improve its durable physio-morphology in vertebrates.

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