Graphical abstract We report the in silico studies and ultrasound assisted Cu-catalyzed synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives as potential ligands for N-protein of SARS-CoV-2.

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: We have synthesized a library of new 1,2,3-triazole incorporated 1,3,4-thiadiazole-isothiazolo[4,3-b]pyridine derivatives 12a-j and have screened these products for their anticancer activities against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer), and MDA MB-231 (breast cancer) using MTT assay with etoposide is positive control. Among them, compound 12e has shown excellent activities against MCF-7, A549, DU-145, and MDA-MB-231 with IC50 values of 0.53±0.055 µM, 0.18±0.077 µM, 0.10±0.082 µM, and 0.92±0.041 µM, respectively.

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