Extramedullary haematopoiesis (EMH) is a compensatory mechanism that occurs when there is deficient bone marrow haematopoiesis secondary to either peripheral red cell destruction or marrow replacement. 1 EMH is the appearance of haematopoietic tissue outside of the bone marrow, which may be composed of two or three haematopoietic cell lineages. 2 In routine cytology practice, it is unusual to encounter extramedullary proliferations of bone marrow elements. EMH is a rare complication of chronic myeloid leukaemia (CML) which can be encountered in the liver, spleen and, rarely, in the lymph nodes. The development of EMH in CML does not usually affect the prognosis of patients; however, the presence of a marrow proliferation in a lymph node would indicate an immediate search for an underlying bone marrow neoplasm and prompt a haematological evaluation, including review of haemogram, peripheral blood smear, and possibly a bone marrow aspiration and biopsy. 3 Here, we report a case of EMH in the axillary lymph node of 67-year-old man with CML in chronic phase which was diagnosed on cytology based on the identification of all the three lineages of haematopoietic cells with a background of reactive lymphoid cells.
| C A S E REP ORTA 67-year-old man presented to medicine outpatient department with easy fatigability, early satiety, dyspnoea on exertion and weight loss for 2 months. He had no complaints of fever and bleeding manifestations or any history of hospitalisation. On physical examination, he had pallor, left axillary lymphadenopathy and splenomegaly.The axillary lymph node which measured 2 × 2 cm was firm, mobile and non-tender. The patient was subjected to fine needle aspiration (FNA) cytology from the axillary node with a clinical possibility of tuberculosis. May-Grünwald Giemsa-and Papanicolaou stained smears revealed a polymorphous population of reactive lymphoid cells admixed with few neutrophils, eosinophils, occasional basophils and tingible body macrophages. In addition, there were scattered large giant cells with lobulated nuclei and some giant cells with large round nuclei, simulating the morphology of large and small megakaryocytes, respectively. Furthermore, we could appreciate a few precursor forms of myeloid and erythroid lineage cells. There was no granuloma or malignancy. Hence, we reported the smears as suggestive of extramedullary haematopoiesis with a note for detailed haematological evaluation (Figures 1A-D and 2A).On haematological evaluation, he was found to have a total leucocyte count of 369.57 × 10 9 /L, haemoglobin 55 g/L and platelets 161 × 10 9 /L. A peripheral blood smear showed hyper-leucocytosis with myeloid bulge and blast accounting for less than 2% with basophilia ( Figure 2B). The haematological diagnosis was CML-chronic phase (BCR-ABL1 positive proven on peripheral blood). Later, bone marrow examination revealed 100% cellularity and myeloid hyperplasia with a full range of maturation. The blast cells constituted <5% on morphology as well as on immunohistochemistry for CD34 and C...