A novel azo schiff base dye (L) have been Synthesized a reaction of 5-[ 2-(5-nitro thiazolyl)azo] -2-amino -4-methyl pyridine (NTAPy) with 4-chloro benzaldehyde in alkaline solution . Anew series of complexes with Ag(I), Au(III) and Pt(IV) ions were Prepared forming chelate complexes. The structure of azo schiff base ligand and its metal complexes were characterize by different spectral technique such as 1 H-NMR, 13 C-NMR, mass spectrum, FT-IR, electronic spectra, C-H.N.S analysis, maganetic susceptibility, atomic absorpotion and molar conductivity. The analytical data suggest the mole ratio [ M:L] was [l:l] for Ag(I) and Au(III) ions but [l:2] for Pt(IV) ion. The metal complexes of Au(III) and Pt (IV) was l:l and l:2 electrolyte receptivity while the Ag(I) complex is non electrolyte . In this study the cytoxicity of Ag(I), Au(III), and Pt (IV) complexes on human (PC3) breast cancer and normal cells were MTT assay. The metal complexes showed selective cytotoxicit against breast cancer , this metal Complexes excelled in halting proliferation of PC3 cancer cells with median inhibitory concentration (lC50) values of Mg/ml , µg/ml and µg/ml for Ag(I),Au(III) and Pt(IV) complexes. The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of pharmacy breast cancer.

A novel hetrocyclic mono azo dye ligand 5-[2-(5-nitro thiazolyl)azo]-2-amino-4-methyl pyridine (NTAPy) was prepared by coupling reaction between 5-nitro thiazole diazonium chloride with 2-amino-4-methyl pyridine in alkaline alcoholic solution . Anew series of some transition metal complexes of Cr(III) , Mn(II) , Fe(III) , Co(II) , Ni(II) , Cu(II) and Zn(II) ions were prepared forming seven chelate complexes . The prepared hetrocyclic mono azo dye ligand and its metal complexes were checked by different spectral technique such as

The study deals with synthesizing new thiadiazole compound (2-(5-amino-1,3,4-thiadiaz0l-2-yl)-4,6-dinitrophenol)(1) by reaction of 3,5-dinitrosalicylic acid with thiosemicarbazide in Phosphoric chloride, then it is (1) reacted with 2-Bromobenzaldehydeto getting Schiff base (2-(5-((2-bromobenzylidene) amino)-1,3,4-thiadiaz0l-2-yl)-4,6-dinitrophenol)(2). T0he compound (2) will reacted with (chloroacetylchloride, thioglycolic acid, glycine, sodium azide, phthalic anhydride) to give (β-lactam, thiazolidine, imidazolidine, tetrazole, oxazepine) derivatives respectively. The new synthesized compounds have been identified by their melting points, 1H-NMR, 13C-NMR and FT-IR spectra. Then the biological activity studied for all the synthesized derivatives toward two type of bacteria.

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