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This research determined to examine the influence of stress on the performance of healthcare workers in the Azad Kashmir region and the role of burnout as a mediator. A survey opinion poll was utilized to gather information from 387 workers in the healthcare industry, and a quantitative methodology was employed to analyze the data. The data were analyzed using descriptive statistics, correlation and regression, and reliability analyses. The results revealed that stress had a negative effect on employee performance and a positive relationship with burnout. Burnout was also found to be negatively associated with worker performance. Furthermore, the results from regression analysis revealed that burnout significantly mediated the relationship between stress and worker performance. These findings suggest that decreasing stress and burnout could increase worker performance in the healthcare industry. This study offers valuable insights into the importance of interventions to manage stress and burnout for employee well-being and organizational outcomes in the healthcare sector.