Now a days the IC Engines are widely used. Connecting rod is used to connect the piston to the crankshaft. As it plays very important role its analysis should be carried out. In this presented work connecting rod of two-wheeler is modeled using CATIA v5 R21 software. After modeling of connecting rod it is made available for analysis in ANSYS. In the ANSYS Workbench static analysis of connecting rod is performed. Analysis is performed for different materials like Cast iron, Copper alloy, Silicon anisotropic, Structural steel and Titanium alloy to find Von misses stress coming on the connecting rod. From above analysis it is shown that Titanium alloy is most suitable material for the two wheeler connecting rod.