Background: Kikuchi-Fujimoto Disease (KFD) is a rare disease and is commonly seen in Asian population. It usually presents with prolonged fever, leukopenia and persistent cervical lymphadenopathy. It is a benign disease with a female preponderance. The cause is unknown but many theories have been postulated, like autoimmune, inflammatory, infectious agents and molecular mimicry. Most of the patients will recover themselves without any sequelae, in six-month time. However, it may rarely also convert to autoimmune disease, like SLE. The recurrence rate is very low. It is important to consider it as a differential diagnosis in chronic persistent lymphadenopathy, like tuberculosis, lymphoma, HIV and autoimmune lymphadenitis. Cases: Here we present a case of a 37-year-old female who initially went to a private practitioner with chief complaint of a persistent neck mass of approximately 6 months duration, multiple small joints pain and persistent fever. She underwent excisional biopsy for suspected lymphoma, but final pathology rendered a diagnosis of KFD. Second case also presented with multiple neck swelling and joint pains, suspect of SLE, connective tissue disorder or young-onset still's disease was made clinically but excisional biopsy revealed KFD. Both the patients improved with NSAIDS and low dose wysolone therapy. Conclusion: The purpose of this article is not only to review the literature but also to create awareness of this entity in the differential diagnosis of persistent lymphadenopathy, especially for the general otolaryngologist in a community-based setting. In addition, this review would be beneficial for other practitioners as well, specifically paediatricians, infectious disease physicians, rheumatologists, pathologists, and medical oncologists.

Guillain Barre syndrome (GBS) is a rare autoimmune neurological disorder that has been reported to carry a high maternal risk and maternal mortality risk of >10% if occurred during pregnancy. It is characterized by acute onset of symmetrical ascending paralysis with or without respiratory depression and autonomic dysfunction secondary to gastrointestinal or respiratory infection. This is case report of 30 years old multigravida who presented at 19 weeks period of gestation with sudden onset back pain and bilateral lower limb weakness that progressed to involve bilateral upper limbs with respiratory insufficiency.  Based on clinical presentation and relevant investigations like serum electrolyte, arterial blood gas analysis and nerve conduction studies, provisional diagnosis of GBS was made. In collaboration with the physician, she was managed with ventilator support for 12 days, intravenous immunoglobulin and supportive therapy. This was followed by complete and rapid recovery as she was extubated on 12th day and discharged on day 16. Patient was followed by strict maternal and fetal surveillance. She successfully delivered a healthy boy at 38 weeks of period of gestation by caesarean section done in view of meconium-stained liquor grade 3 in early labour and she was discharged on day 3 of LSCS.

Aims and Objective: To study and compare coagulation profile in normal pregnancy, pregnant women at high risk, non-pregnant women and pregnancy outcome. Method: This comparative prospective study was done in tertiary healthy care centre of north India for over period of one year. Result: Total 230 cases were taken, out of which 222 antenatal cases were unbooked cases with no antenatal visits along with 8 non-pregnant healthy women. Cases were further divided into three groups of non-pregnant women, normal pregnant women and pregnant women at high risk. All groups were compared for derangement of coagulation profile and pregnancy outcome in terms of adversity. In normal pregnant women (Group-1), there were 2 cases (94.4%) of deranged coagulation with isolated thrombocytopenia. In pregnant women at high risk (Group-2), 31 cases (16.6%) were having deranged coagulation out of which maximum cases were of eclampsia- preeclampsia spectrum (eclampsia and HELLP syndrome) followed by anaemia, placental abruption and placenta previa. In terms of adverse pregnancy outcome, maximum mortality was again in ecalmpsia and HELLP syndrome cases. In adverse perinatal outcome along with eclampsia and HELLP syndrome, preterm labour and FGR was a significant factor. Conclusion: Hypertensive disorders of pregnancy remain the main cause of deranged coagulation and adverse outcome in high risk pregnancy group along with anaemia and liver disease.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of the disease (COVID-19) at present. Our understanding of the impact of the virus on the nervous system is limited. The involvement of CNS and neurological manifestations reports are further limited in obstetrical cases. We are reporting a case of an unusual presentation of COVID-19 infection in an admitted P2L2 postpartum woman who developed multiple episodes of seizures on postpartum day 8 of lower segment caesarean section, with no prior history of seizures or hypertension. This report will add to a rare neurological manifestation of COVID-19 in pregnancy.

Background:The objective of the study was to study maternal and fetal outcome in pregnancy complicated with deranged liver function test and jaundice.Methods: Total 150 antenatal patients with clinical or laboratory evidence of abnormal liver function test and jaundice were selected for study done for a period of one-and-half year at a tertiary care hospital in north India.Results: All cases were in their third trimester of pregnancy out of which 93.3% were unbooked cases. Most of the patients presented with pregnancy induced hypertension, fever and jaundice at time of admission. Other presenting complaints were nausea, vomiting, pedal edema, abdominal pain and including 3 cases of altered sensorium. Acute viral hepatitis was most important cause of jaundice in this study followed by preeclampsia and ICP were other causes of jaundice in this study. Hepatitis B was the most common cause of acute hepatitis (26.7%) followed by hepatitis C (6.7%). Maternal mortality was seen in 4 cases (3 cases of Eclampsia & HELLP syndrome and one case of multi-organ failure). 138 patients were kept in ICU for intensive monitoring. Preterm delivery was most common maternal complication. Of all the deliveries, 26.7% were preterm, 31(21%) were IUFD, 57(38%) had fetal distress with meconium stained liquor, 27 (18%) had PROM, 50 (33%) had fetal growth restriction.Conclusions: Deranged liver function and jaundice in pregnancy results in a very high perinatal as well as maternal morbidity and mortality, and requires an early diagnosis and intensive care management.