Background: Family interventions are the core interventions in which mental health professionals provide support and understanding of the illness to affected individuals and family members. They work together on planning treatment; provide psychological support and understanding of the disorder. Aim: To study the impact of the family intervention on self-esteem and wellbeing of individuals with alcohol dependence syndrome. Methodology: It was a hospital-based pre-post design intervention study. Ten samples purposively selected and equal numbers were assigned to the experimental and control group. Tools used for assessment were - a semi-structured socio-demographic and clinical data sheet, Rosenberg Self-Esteem Scale, PGI General Well-being, and The McMaster Family Assessment Device. Results: The study results show that family intervention brings significant improvement in the family functioning; self-esteem and well being of the study sample which sustained over three months follow up period. Conclusion: This line of treatment can be used for better outcome among persons with alcohol dependence syndrome. Keywords: Alcohol dependence, family interventions, self-esteem, wellbeing