Background: Resistin, a novel hormone, got its recognition as a regulator of lipid metabolism in obese rodents. Human researches proved its role mainly in inflammation and to lesser extent in obesity. Aim: To observe the relationship of serum resistin with body mass index (BMI) and lipid levels in hypertensives and ischemic heart disease patients as compared to normal subjects. Methodology: Eighty participants between the ages of thirty to fifty five years were distributed in four groups including normal subjects, first time diagnosed patients of hypertension, and first time diagnosed hypertensive cases of stable angina pectoris and myocardial infarction respectively. After history and general physical examination, fasting blood samples of the participants were tested for serum resistin by using the enzyme linked immunosorbent assay technique and lipid profile with commercially available enzymatic kits. Analysis of the data was performed by SPSS version17.0. Results: In patients of research groups, statistically raised levels (mean±SD) of BMI, and serum values of resistin, triglycerides, low-density lipoproteins (LDL) while decreased high density lipoproteins (HDL) levels were documented in comparison with healthy subjects. Conclusions: There are significantly higher values of body mass index, blood resistin, triglycerides and LDL while lower serum HDL levels in hypertensives and patients of ischemic heart disease as compared to normal participants. Keywords: Resistin, ischemic heart disease, lipid profile, body mass index

Background: Myocardial ischemia is considered as one of most common cause of mortality worldwide. Several Risk factors are linked to an increased incidence of Myocardial Ischemia. The most common risk factors are hypertension, hypercholesterolemia, diabetes mellitus, high BMI, physical inactivity, smoking, age and gender predisposition and socioeconomic status. Aim: To inspect and compare incidence of myocardial ischemia in cases with hyperlipidemia and elevated BMI. Methods: 102 patients were selected for our research study and cases were split up into 2 groups of 51 patients each. Group A comprised cases with standard normal lipid profile and BMI with suspected myocardial ischemia. Group B contained 51 patients with hyperlipidemia and high BMI with suspected myocardial ischemia. The study data was then analyzed by SPSS 21st version. The Probability Value (P- Value) of ≤0.05 was coined as statistically convincing value. Results: The serum Cholesterol levels were 148 ± 11 in first group A and 268 ± 41 in other group B. The triglycerides serum values were 129± 13 in A group and 220± 13 in B group. The serum Low density Lipoproteins values were 109±10 in A group and 179±22 in B group. The serum HDL values were 39±10 in A group and 20±08 in B group. An independent/unpaired samples T- statistical test was used Using a two-tailed 0.05 criterion, the test indicated a statistically convincing difference among the two research groups (p value was <0.05) in relation to cholesterol, triglycerides, HDL, LDL and BMI. Conclusion: Hyperlipidemia and High BMI contribute significantly to development of acute myocardial ischemia Keywords: Myocardial Ischemia, Hyperlipidemia, Body Mass index

Background: Hypercoagulation is hallmark complication of Diabetes mellitus where increased coagulability of blood manifests in the form of more clot formation. Type 2 Diabetes Mellitus is a longstanding metabolic abnormality indicated by elevated sugar values in blood and insulin resistance. Aim: To evaluate role and association of serum triglycerides levels in onset and progression of diabetic nephropathy. Materials: 120 patients are included in our study and cases are managed into 02 groups(60 patients each group). A Group: included diabetic cases without nephropathy B Group: included 60 diabetes patients with nephropathy The study data was then analyzed by software SPSS 21 number version. The Probability (P statistical Value) value of < 0.05 was decided as convincing number statistically. Results. The serum triglycerides levels were 159± 13 in A group and 210± 13 in the B group. The unpaired(independent) samples T- statistical test was utilized Using a two-tailed 0.05 criterion, the test showed remarkable difference between the two groups statistically (p value was < 0.05) in relation to serum triglycerides. Based on the inferences of the unpaired (independent sample) t- statistical test (p value was less than 0.05), we repudiated the null statistical hypothesis. Conclusion: Hypertriglyceridemia plays significant part in onset, development and progression of nephro-pathy in diabetic patients. Keywords: Hypertriglyceridemia, Diabetic Nephropathy, Diabetes Mellitus