TiO2 based photocatalyst has potential material for disinfection of harmful pathogens as well as removal of organic compounds. The formation of reactive oxygen species is a key part for overall process but aggregation and band gap constraint explore a new dimension to use of support for propounding its physicochemical properties. Therefore, the modification of TiO2 using various support alters photocatalytic action and promising ways of the mechanism based on nature of substrates and environments. In addition, the immobilization of nano dimension photocatalyst may reduce overall cost of operation and recovery of photocatalytic materials. In this perspective, extensive range of support materials as carbonaceous matters, clay, polymers, metal oxides have been studied by various researchers; that have been compiled in this review article. The properties of support were the key features for the assortment of appropriate supports for increase its efficiency as photocatalyst. In brief, overall TiO2 based photocatalyst supported on various substrates pave the ways toward new strategies for water disinfection.