Extramedullary plasmacytoma (EMP) is a rare form of plasma cell neoplasm that originates from B lymphocytes. It accounts for only 4% of all plasma cell disorders. We present two cases of EMP that were diagnosed in two different locations. The first case is a 55-yearold presented with epistaxis and sinusoidal polyps. Histologic examination disclosed plasmacytoma. The second case is a 69-year-old patient presented with upper airway obstruction caused by laryngeal mass and histologic examination revealed plasmacytoma of the larynx. Our cases are unique in their presentation and anatomic locations. To our knowledge, sinusoidal and laryngeal occurrences of the disease are only reported in a handful of cases. Both cases were treated mainly with radiotherapy. The postoperative phase was uneventful.