Recent advances in adaptive polymeric hydrogels have witnessed broad applications in adhesion, [1-3] tissue engineering, [4] wearable electronics [5-7] and soft robotics. [8] Due to the dynamic and configurable nature of noncovalent bonds, hydrogels composed of physically cross-linked networks exhibit appealing properties such as external stimuli-responsiveness, [9,10] antifatigue, [11,12] self-healing, [13,14] shape-memory, [15,16] and recyclability. [17,18]

Thermal energy storage technologies based on phase‐change materials (PCMs) have received tremendous attention in recent years. These materials are capable of reversibly storing large amounts of thermal energy during the isothermal phase transition and offer enormous potential in the development of state‐of‐the‐art renewable energy infrastructure. Thermal conductivity plays a vital role in regulating the thermal charging and discharging rate of PCMs and improving the heat‐utilization efficiency. The strategies for tuning the thermal conductivity of PCMs and their potential energy applications, such as thermal energy harvesting and storage, thermal management of batteries, thermal diodes, and other forms of energy utilization, are summarized systematically. Furthermore, a research perspective is given to highlight emerging research directions of engineering advanced functional PCMs for energy applications.

By effectively regulating noncovalent interactions and thus the structure of polymer networks through the solvent exchange strategy, in article number 2004579, Yan Qiao, Dong Qiu, and co‐workers develop a class of stiff and antiswelling hydrogels (named as exogels). The spatial and temporal progression of the exogels via solvent exchange also make them applicable for robust underwater adhesion.

No abstract

Myocardial ischemia-reperfusion injury (MIRI) is a serious threat to the health and lives of patients without any effective therapy. Excessive production of reactive oxygen species (ROS) is considered a principal cause of MIRI. Some natural products, including ginsenoside Rg3 (Rg3), exhibit robust antioxidant activity. However, the lack of an effective delivery strategy for this hydrophobic compound hinders its clinical application. In addition, therapeutic targets and molecular mechanisms of Rg3 require further elucidation to establish its mode of action. This study aimed to generate ROS-responsive nanoparticles (PEG-b-PPS) via the self-assembly of diblock copolymers of poly (ethylene glycol) (PEG) and poly (propylene sulfide) (PPS) and use them for Rg3 encapsulation and delivery. We identified FoxO3a as the therapeutic target of Rg3 using molecular docking and gene silencing. In rat ischemia-reperfusion model, an intramyocardial injection of Rg3~loaded PEG-b-PPS nanoparticles improved the cardiac function and reduced the infarct size. The mechanism of action was established as Rg3 targeting of FoxO3a, which inhibited the promotion of oxidative stress, inflammation, and fibrosis via downstream signaling pathways. In conclusion, this approach, involving ROS-responsive drug release, together with the identification of the target and mechanism of action of Rg3, provided an *