AIM:To analyze, evaluate and compare OCT and VEP findings in various optic nerve disorders. MATERIALS AND METHODS:This is a prospective cross sectional study. Patients with optic neuropathies are investigated with OCT and VEP. The RNFL thickness will be analyzed with spectral domain OCT.VEP analysis will be done for assessing the amplitude and latency of the wave forms. The results of OCT and VEP will be compared and analyzed for various optic nerve disorders. RESULTS: Totally 128 eyes of 84 patients with optic nerve disorders were included in the study. All the eyes of early papilledema showed increased RNFL thickness whereas only 15% showed prolonged P100 latency and 35% showed decreased amplitude. All the eyes with established papilledema showed increased RNFL thickness whereas 55.6% showed prolong P100 latency and 61.1% showed decreased amplitude. All the eyes with chronic papilledema showed increased RNFL thickness as well as prolonged P100 latency but only 30% showed decreased amplitude. All the eyes with AION showed increased RNFL thickness and decreased amplitude but 71.4% showed prolonged P100 latency. Among the eyes with Inflammatory ON, 57.1% showed increased RNFL thickness whereas all the Inflammatory ON eyes showed prolonged P100 latency and 42.9% showed reduced p100 amplitude. Among the eyes with Traumatic ON only 8.3% showed decreased RNFL thickness whereas all the eyes with Traumatic ON showed prolonged P100 latency and 83.3% showed decreased amplitude. Among the eyes Optic atrophy, 86.7% showed decreased RNFL thickness, 96.2% showed prolonged p100 latency and 80.8% have reduced amplitude. The pvalue is not significant. CONCLUSION: OCT can be considered as the primary investigation to diagnose the stage of papilledema and VEP can assess the severity. VEP helps in differentiating AION from early papilledema. OCT is less sensitive than VEP in Inflammatory ON. VEP can be considered as diagnostic test for acute traumatic optic neuropathy. Both OCT and VEP plays equal role in the diagnosis of optic atrophy.

Central Serous Chorioretinopathy (CSCR) is the detachment of the neurosensory retina and/or Retinal Pigment Epithelium (RPE) due to accumulation of fluid in the sub retinal space, mostly confined to the macula. Hereby, presenting a rare case of a 32-year-old patient with defective vision in both eyes, she was a known case of Chronic Kidney Disease (CKD) on haemodialysis. On examination best corrected visual acuity was 6/9, on dilated fundus examination with ring reflex in both eyes, Optical Coherence Tomography (OCT) macula showed detachment of the neurosensory retina from RPE with the sub retinal fluid. This case is considered to be rare due to the unusual association noted between CSCR and End State Renal Disease (ESRD), in a female patient with no history of usage of corticosteroids or known identifiable risk factors. Hence, it is essential to screen patients with ESRD for CSCR to prevent vision threatening complications.