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Summary Pyoderma gangrenosum is a rare occurrence in patients with haematological malignancy. This characteristic but nonspecific inflammatory process with skin destruction occurred in 4 patients with myelodysplasia, in one with acute leukaemic transformation of myelofibrosis, and in de novo acute myeloblastic leukaemia in another. Clinically, the cutaneous lesion in these patients differed from that associated with inflammatory bowel disease, arthritis, or the idiopathic type of pyoderma gangrenosum by having the vesiculo-bullous borders. Histopathological differences were also evident since more superficial layers of the skin were involved in the ulceration than typically encountered in patients with non-malignant systemic disease. Despite the less penetrating nature of this variant, treatment of the pyoderma gangrenosum is unsatisfactory and in the absence of effective therapy for the underlying disease, healing occurred only in the patient with acute leukaemia who achieved complete remission in response to chemotherapy.

Invasive species pose a significant threat to communities and ecosystems around the world affecting social, political and ecological conditions. The Asian Longhorned Beetle (ALB) is one such pest that has affected parts of North America, including central Massachusetts. The United States Department of Agriculture (USDA) felled more than 30,000 trees there as part of an ongoing eradication effort. In this paper, we draw on relational place-making theories to consider multi-scalar social vulnerability, and livelihoods frameworks to assess the social, political, and ecological factors that contributed to vulnerability and responding adaptations in Worcester, MA. Interviews with stakeholders identified vulnerabilities and emerging policy -including a new non-governmental organization-that has increased resilience, despite some institutional weaknesses in the capacities of the local government. Future research will explore ways to institutionalize long-term tree stewardship at the municipal level, and the socio-spatial impacts of emerging policies.

The regeneration of peripheral blood cells in six patients receiving ABO incompatible bone marrow transplants for severe aplastic anaemia has been studied. The results are compared with those of 18 similar aplastic patients treated with ABO compatible transplants. Reticulocyte recovery in the ABO incompatible cases was significantly delayed (P less than 0.01) and associated with greatly prolonged red cell transfusion requirements (P less than 0.001). Peripheral blood regeneration of neutrophils, lymphocytes and platelets was also significantly delayed (P less than 0.01). Platelet support was required for longer in the ABO incompatible cases (P less than 0.001) but there was no increase in the incidence or severity of infections in the post transplant period.