Coexisting anti‐MDA5 and anti‐PL‐7 antibodies are extremely rare. Anti‐MDA5 is associated with rapidly progressive interstitial lung disease (RP‐ILD), while anti‐PL‐7 is often associated with chronic or subacute ILD and better outcomes than RP‐ILD. We report a 41‐year‐old woman diagnosed with dermatomyositis (DM)‐associated ILD positive for anti‐MDA5 and anti‐PL‐7.
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) and
anti-threonyl-tRNA synthetase (anti-PL-7) are myositis-specific
autoantibodies, associated with rapidly progressive interstitial lung
disease (RP-ILD). A 41-year-old woman presented productive cough,
dyspnea, and muscle pain. Anti-MDA5 and anti-PL-7 were double-positive.
The patient was diagnosed with dermatomyositis-associated ILD, and
responded successfully to glucocorticoids and immunosuppressants.
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