High-efficiency electromagnetic interference (EMI) shielding and heat dissipation synergy materials with flexible, robust, and environmental stability are urgently demanded in nextgeneration integration electronic devices. In this work, we report the lamellar MXene/Aramid nanofiber (ANF) composite films, which establish a nacre-like structure for EMI shielding and heat dissipation by using the intermittent filtration strategy. The MXene/ ANF composite film filled with 50 wt % MXene demonstrates enhanced mechanical properties with a strength of 230.5 MPa, an elongation at break of 6.2%, and a toughness of 11.8 MJ•m 3 (50 wt % MXene). These remarkable properties are attributed to the hydrogen bonding and highly oriented structure. Furthermore, due to the formation of the MXene conductive network, the MXene/ANF composite film shows an outstanding conductivity of 624.6 S/cm, an EMI shielding effectiveness (EMI SE) of 44.0 dB, and a superior specific SE value (SSE/t) of 18847.6 dB•cm 2 /g, which is better than the vacuum filtration film. Moreover, the MXene/ANF composite film also shows a great thermal conductivity of 0.43 W/m•K. The multifunctional MXene/ANF composite films with high-performance EMI shielding, heat dissipation, and joule heating show great potential in the field of aerospace, military, microelectronics, microcircuit, and smart wearable electronics.

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KRN7000 has widely biological activities, such as anti-tumor, anti-tuberculosis, anti-fungal, anti-virus, anti-inflammation, and against auto-immune diseases. As the potential immunomodulator, KRN7000 can effectively activate the natural killer T cells (NKT cells) and induce the secretion of IFN-γ and IL-4 cytokines. However, IFN-γ inhibited the activity of T helper 2 cells (T H 2) and IL-4 inhibited the activity of T helper 1 cells (T H 1), which mediated humoral as well as celluar immune reactions, respectively. The concomitant of functions of T H 1 and T H 2 limits the therapeutic potential of KRN7000 against immune diseases. Therefore, developing new analogues of KRN7000 to find new immnostimulating drugs has drawn many attentions in the world. This review presents the recent progress in the study on the structure and immune activity of the synthesized KRN7000 derivatives. [6] 以及治 疗自身免疫性疾病(如系统性红斑狼疮 [7] 、糖尿病 [8] )等. 其中, 其高效的免疫调节活性最引人注目. 研究表明 KRN7000 可以通过活化自然杀伤 T 细胞(NKT)促进细 胞因子 IFN-γ 和 IL-4 的释放 [9] . KRN7000 可与 CD1d 蛋 白(CD1 蛋白质的一种, 可通过分泌脂质抗原活化 NKT 细胞)识别结合, 形成 CD1d/KRN7000 二元复合物, 进 而被 NKT 细胞表面的受体(TCR)识别, 形成具有免疫活 性的"CD1d 蛋白/KRN7000/NKT 细胞"三元复合物, 交互刺激 γ 干扰素(IFN-γ)及白介素 4 (IL-4)两大细胞因 子的释放 [10,11] . 这些细胞因子分别诱导 T 辅助细胞 1