Objective: The objective of this research work was to formulate and evaluate topical gel loaded with cefixime trihydrate, a third-generation cephalosporin antibiotic for the treatment of bacterial wound infections. Methods:The cefixime trihydrate gel was formulated using polymers such as Carbopol 940 and hydroxypropyl methylcellulose E4M in varying concentrations. Three different formulations were prepared and characterized physically for color, syneresis, spreadability, pH, drug content, and rheological properties. In vitro drug release in phosphate buffer pH 7.4 and antibacterial study were performed for the gel formulation to evaluate its therapeutic effect on wound infections. Results:The study demonstrated that the gel formulations showed promising results on their physical evaluation tests. The rheology behavior of the gel was shear-thinning flow type which indicated easy spreading of the gel. The drug release of the gel formulation F2 was selected as the best due to its highest drug release rate of 32.2% in comparison with the other two formulations after 2 h of the study. F2 formulation possessed the highest antibacterial activity as compared to other two formulations. Conclusion:A pioneering work was done on formulating cefixime trihydrate as a gel for topical administration. The antibacterial effect of the drug as gel formulation showed promising effect. We conclude that the cefixime trihydrate could be successively loaded into a gel formulation and can be used for effectively for wound infections like diabetic foot wounds.

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Needle-stick injury (NSI) is one of the maximum potential risks for health care people. They pose a substantial risk of occupational transmission of blood-borne pathogens. Many numbers of health care people remain susceptible to deadly viruses especially, bloodborne pathogens. Dental professionals are more prone to Needlestick injury due to their limited working area. The main cause of this injury is due to improper capping of the needle, a technique used, handling the specimens, etc. The present study was done to determine knowledge and attitude about needle stick injury among dental practitioners and the action taken by them after the incident. A self-designated 15 questions were created and it was circulated among 100 dental practitioners. The results were collected and analyzed using SPSS. An effective plan should be made for the prevention and management of injury especially among health care professionals. Among 100 responses most of the people do not follow the protocol which indicates that there is a lack of adequate knowledge. From this study, we conclude that only 50% of the study population were aware about the needle stick injury and the infections spread by Needle stick injury. Even though a majority of the females knows about the Hepatitis B vaccination and its relation to needle stick injury when compared to males but they didn't undergo vaccination properly. There is a precise scope of development in terms of reporting and prevention of needlestick accidents.A need for awareness programs among dental practitioners repeatedly has been raised