Journal of Manufacturing Technology Management 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 F o r P e e r R e v i e w IntroductionThe modern marketplace is commonly characterised in many sectors by hypercompetition, a state, which has accrued over many years (D'Aveni 1994). Hypercompetition has been driven by the combined impact of macro-forces changing the nature of both supply and demand. On the supply side, environmental factors such as the increasing globalisation and deregulation of commerce have opened up markets to be provided for by a greater volume of companies (Harvey et al. 2001). This has combined with the development and adoption of new technologies, which has enhanced the sophistication of supply capabilities (Harvey et al. 2001). On the demand side, customers, presented with this increased proliferation and sophistication of choice in supply, are characterised by a growing assertiveness in seeking out better and better values when selecting products and services (Bhamu and Sangwan 2014).For organisations, hyper-competition has led to a realisation that more demanding rules for business now exist to be successful in the modern age. There needs to be a full recognition of what customers' value combined with a focus on the optimisation of operating processes to effectively compete in serving customers (Bowersox et al., 2000). The "Lean" business ideology (Bhasin 2013), which has been one of the dominant research areas in Operations Management (Voss 1995, Shah andWard 2003), has thus been turned to by many organisations to guide their mind-set and efforts in addressing these needs. Lean sets out a methodology for being highly responsive to customers' demands whilst constantly challenging costs and wastes throughout supply networks (Bhamu and Sangwan 2014, Shah andWard 2007). So, it would appear that Lean can be applicable to all sizes of enterprise in their endeavours to become more competitive to sustain, and possibly enhance, their position in the modern marketplace. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 F o r P e e r R e v i e w Broadly, organisations can be simply categorised into two groups: Large Enterprises (LEs) and Small and Medium sized Enterprises (SMEs). It would appear however, that there is a significantly lower up take lower take up of Lean in SMEs compared to LEs (Shah and Ward 2003) and that many SMEs are still unfamiliar with Lean implementation (Achanga et al. 2006). Research has indicated that this is due to many factors, which will be further explored and examined in this paper. While several studies that have addressed Lean implementation in general (e.g. Hines et al. 2004, Holweg 2007, Moyano-Fuentes and S...

PurposeThe purpose of this paper is to take a critical, analytical approach to explore the growth and spread of Lean through the academic and practitioner community over the last twenty-five years to understand the impact of the book The Machine that Changed the World on management thinking. Design/methodology/approachA comprehensive and systematic review of the extant literature of lean was undertaken and analysed critically to observe patterns and trends that could explain the acceptance of Lean as an operations management philosophy. The review spans from 1987 to 2013. To enable us to effectively manage and understand the diffusion of this literature a database, the Lean Publications Database (LPD), was constructed. The number of publications has been adjusted to compensate for growth in the total number of articles published in the same period.

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Recruitment of a dynamin-like GTPase (Drp1/Dlp1/Dnm1) to membranes requires the mitochondrial dynamics protein Fis1. Mdv1 has been proposed to act as an adaptor between Fis1 and Dnm1 in Saccharomyces cerevisiae. We show that S. cerevisiae Fis1 binds directly to Dnm1 and to Mdv1. Two Fis1 regions have been previously implicated in Mdv1 recruitment: an N-terminal "arm" and a concave surface formed by evolutionarily conserved residues in the tetratricopeptide repeat domain. Perturbing either Fis1 region does not affect Mdv1 binding, but both regions influence Dnm1 binding. Fis1 lacking its N-terminal arm binds tightly to Dnm1, and binding is abolished by mutations to the Fis1 concave surface. The Fis1-Dnm1 interaction decreases more than 100-fold in the presence of the Fis1 arm, suggesting that the arm acts in an autoinhibitory manner to restrict access to the Dnm1 binding site on Fis1. Our data indicate that the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted.