The present study was conducted with specific objective to study the Entrepreneurial Eehaviour of Turmeric Growers in Hingoli District the study was conducted in Hingoli District of Maharashtra. The study was purposively conducted in Vasmat and Aundha tahsils of Hingoli district as a major area under turmeric cultivation. Keeping in view the objectives of the study, an interview schedule was designed. This includes relevant questions for seeking information in respect of independent and dependent variables. The data were collected through face to face contact method by contacting the selected farmers. The majority 61.34 per cent of respondents were from middle age group, followed by old age group 25.33 per cent and young age group 13.33 per cent respectively, the majority 38.00 per cent of respondents were educated up to High school, where as one third 24.67 per cent up to College level. About 16.67 per cent respondents educated up to Middle school and very few 11.33 per cent was found in primary whereas 06.00 per cent and 03.33 per cent of the respondents are illiterate and can read and write respectively, the majority, more than half of the turmeric grower 69.33 per cent had medium family size whereas, 22.00 per cent of turmeric grower belonged to small family size, Thus, 08.67 per cent of turmeric growers belonged to big family size the majority 71.33 per cent of the turmeric growers had medium experience in turmeric production for a period ranging between 8 to 17years , followed by 18.00 per cent of respondents had low experience the majority that 77.33 per cent of the respondents had well or tube well their source of irrigation, canal 20.00 per cent and remaining 02.67 per cent of the respondents had river as their source of irrigation. Thus, the study concluded that maximum number of the respondents had well or tube well as their source of irrigation. Maximum percentage of the turmeric growers were found in semi-medium and medium land holding category. The reason for possession of higher per cent of semi medium land holding could be due to fragmentation of land because of separation of families. majority 76.00 per cent had annual income of Rs. 99176 to Rs. 380824, followed by 15.33 per cent of the respondent had annual income of below Rs. 99175 and only 08.67 per cent had annual income of Rs.380822 and above more than two third 64.00 per cent of respondents uses medium sources of information followed by, low 20.00 per cent and high category of sources of information 16.00 per cent respectively. more than two third 64.00 per cent of respondents uses medium sources of information followed by, low 20.00 per cent and high category of sources of information 16.00 per cent respectively the majority 77.33 per cent of the turmeric growers had high social participation, while, 12.67 per cent of turmeric growers were having medium level of social participation. Only, 10.00 per cent of them had low social participation .majority 69.33 per cent of the respondents had medium risk bring ability. Whereas, 20.00per cent ha...

Shprintzen-Goldberg syndrome (SGS) is autosomal dominant disorder with features of craniosynostosis, distinctive craniofacial features, skeletal abnormalities, marfanoid body habitus, aortic dilatation, and intellectual disability. SGS is caused by mutations in the <i>SKI</i> gene, encoding the oncoprotein SKI, a repressor of TGFβ activity. We present the unusual molecular findings in a 12-year-old female child with SGS. There was co-occurrence of 2 heterozygous missense variations, c.346G&#x3e;A (p.Gly116Arg) and c.687G&#x3e;C (p.Lys229Asn), in exon 1 (hotspot) of the <i>SKI</i> gene, which makes this propositus different from all other patients reported in the literature. Both variants were found to be de novo. In silico analysis revealed that both of them are pathogenic, but later on, Gly116Arg was proven to be more pathogenic by various in silico prediction tools. c.687G&#x3e;C (p.Lys229Asn) was found as a single report in ExAC in the South Asian population, but c.346G&#x3e;A (p.Gly116Arg) is not reported anywhere, thereby making it a novel sequence variant in the <i>SKI</i> gene, giving rise to SGS. This case illustrates the issues regarding the importance and difficulties associated with the determination of the causative variations in a single-gene disorder.

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