Self-micro-emulsifying drug delivery system is the one of the approach for enhancing the solubility of the hydrophobic drug. The drugs which are insoluble in water can be formulated in this method by solubilising it in the lipid vehicle to absorb through the membranes. The lipid and surfactants are used to increase the solubility of the drug and improve absorption. This improves the dissolution rate of the drug by increasing its solubility. Many of the hurdles and solutions are described in this article. This technique gained attention as it also enhances the bioavailability of the drug. This article has complete review about SMEDDS for present work and for future perspective also.