At present, the yield of cotton depends on the applied agrotechnological measures, the timing of application, the norm and type of mineral or organic fertilizers, as well as on the natural fertility of the soil, the level of crops and a number of similar measures. Maintaining and improving soil fertility is essential for sustainable agriculture. Its agrochemical properties play an important role in soil fertility. Maintaining and improving soil fertility is essential for sustainable agriculture. Its agrochemical properties play an important role in soil fertility. Cotton nutrition, growth development, yield and product quality depend on the agrochemical properties of the soil and its nutrition regime. Organic fertilizers play an important role in improving soil fertility, especially its agrochemical properties. Organic fertilizers have a complex effect on the soil and have a positive effect on the growth, development and productivity of agricultural crops, including cotton. The main substance that determines soil fertility is humus. The higher the quantity and quality of humus, the higher the yield. However, according to most scientists, the amount of humus in the soil has decreased significantly over the past 30-40 years. Organic fertilizer in fact is an effective influencing factor that improves the quality of the crop. Therefore, it is important to maintain and increase soil fertility, taking into account the properties of organic fertilizers in the soil.