E. coli thioredoxin reductase has been cloned and sequenced [21,22] and its biochemical and physical properties extensively studied [23,24]. Eukaryotic thioredoxin reductases have so far been only cloned from Penicillium chrysogenum [25], Saccharomyces cerevisiae [26], and Arabidopsis thaliana [27] and they show 44-50% sequence identity to the bacterial enzyme. We now report the cloning and sequencing of a putative thioredoxin reductase from human placenta.
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