The development of the Reynolds stress field was studied for flows in which an initially two-dimensional boundary layer was skewed sideways by a spanwise pressure gradient ahead of an upstream-facing wedge. Two different wedges were used, providing a variation in the boundary-layer skewing. Measurements of all components of the Reynolds stress tensor and all ten triple products were measured using a rotatable cross-wire anemometer. The results show the expected lag of the shear stress vector behind the strain rate. Comparison of the two present experiments with previous data suggests that the lag can be estimated if the radius of curvature of the free-stream streamline is known. The magnitude of the shear stress vector in the plane of the wall is seen to decrease rapidly as the boundary-layer skewing increases. The amount of decrease is apparently related to the skewing angle between the wall and the free stream. The triple products evolve rapidly and profiles in the three-dimensional boundary layer are considerably different than two-dimensional profiles, leaving little hope for gradient transport models for the Reynolds stresses. The simplified model presented by Rotta (1979) performs reasonably well providing that an appropriate value of the T-parameter is chosen.
Study Objective To determine whether changes in serum glucose, serum potassium, and plasma insulin levels are correlated in a cohort of hypertensive patients. Design Prespecified subgroup analysis of results from a prospective, multicenter, randomized, open-label, parallel-group study. Setting Primary care clinics at three tertiary care medical centers. Patients Community-based ambulatory population of 202 patients (age range 17–65 yrs) with a new diagnosis of hypertension, untreated hypertension, or known hypertension, who were previously treated with fewer than three antihypertensive drugs and had no evidence of cardiovascular disease or diabetes mellitus. Intervention Monotherapy with oral hydrochlorothiazide 12.5 or 25 mg/day for 9 weeks. Measurements and Main Results Fasting serum glucose, serum potassium, and plasma insulin levels were obtained at baseline (before hydrochlorothiazide therapy was started) and after 9 weeks of therapy. Significant elevations were noted in fasting serum glucose (mean ± SD 3.42 ± 10.38 mg/dl, p<0.0001) and plasma insulin (2.35 ± 9.47 μIU/ml, p<0.0001) levels, and a significant reduction in serum potassium level (0.30 ± 0.44 mEq/L, p<0.0001) was noted. No significant correlation was observed between changes in fasting serum glucose and potassium levels (r = 0.022, 95% confidence interval (CI) −0.120–0.164, p=0.757) or between changes in serum potassium and plasma insulin levels (r = −0.112, 95% CI −0.256–0.037, p=0.140). Changes in serum glucose levels did not differ significantly between patients maintaining serum potassium levels of 4.0 mEq/L or greater and those with levels below 4.0 mEq/L. Conclusion Changes in serum potassium and serum glucose levels were not correlated in individuals receiving hydrochlorothiazide monotherapy; thus maintenance of normal potassium levels may not attenuate the risk of thiazide diuretic–induced hyperglycemia.
The present investigation focused on the reevaluations of "competency to stand trial" (CST) of 75 criminal defendants with mental retardation (MR) who were originally found incompetent and who were referred for treatment. The effect of competency restoration training was examined. Site of training was also investigated. Because habilitation facilities are specially designed to help individuals with MR, it was suspected that training at habilitation centers would have a greater effect on restoration of defendants with MR than the training at state hospitals. Results showed that significantly more defendants did not gain competency following training than those who did. Analysis revealed that (a) higher IQ and (b) being African American rather than Caucasian American were predictive of restoration. When discriminating factors were held constant, site of training did not significantly affect competency restoration. Possible explanations for this finding were discussed.
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