Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the polymers. The characterization of the new polymer okra showed that it has swelling properties, and in spite of being a hydrophilic polymer, it can be successfully used in pharmaceutical formulation as a good binder.Conclusion: In the present aspect of the study was to evaluate the efficacy of okra gum that has been used as a tablet binder. It is easily available and inexpensive. Okra gum as a binder produces tablet formulations with good physicochemical properties and good candidate for sustained release formulations.

Protein based nanoparticles are investigated size, container-like shape, natural source, biocompatibility, and biodegradability. range in size from about 1-1000 nanometers in diameter, about one thousand in a human body. These are made up by a variety of materials including metals, polysaccharides, and proteins which having biodegradability, bioavailability, and relatively low cost in nature. protein nanoparticles are e to process and can be modified by desired flexible fabrication, and high surface Nanoparticles can be made from a var Biological protein-based nanoparticles such as silk, keratin, collagen, elastin, corn zein, and soy protein nanoparticles are advantageous in having biodegradability, bioavailability, of protein based nanoparticles has recently use protein like albumin, gelatine. The techniques for their fabrication include emulsification, de coacervation, and electro-spray. The administration are explored and reported by the protein nanoparticles as drug delivery carriers.

The review on the significance of microbubbles is about the size, preparation, drug loading methods and uses of microbubbles in various fields like pharmaceutical, biotechnology, diagnostic and research applications. The size of the microbubbles ranges between one micrometer and one millimeter. They are used in medical diagnostics as a contrast agent for ultrasound imaging. The gas-filled microbubbles oscillate and vibrate, when a sonic energy field is applied and may reflect ultrasound waves. This distinguishes the microbubbles from surrounding tissues. Microbubbles must be encapsulated with a solid shell which is made from either a lipid or a protein such as Optison microbubbles consisting of perfluoropropane gas, encapsulated by serum albumin shell. Microbubbles are used to carry a drug or gene to a specific area of interest and where the ultrasounds burst them, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-coated microbubbles to adhere to vascular regions with glycocalix damage or endothelial dysfunction is another possible mechanism to deliver drugs even in the absence of ultrasound. Its scope extends beyond conventional microbubbles to all other small particulate systems such as self assembling structures that involve preparative manipulation.

Aim/background: Microspheres are spherical particles, having a core, having a particle size of 1µm to 1000µm. They are advantageous as compared to conventional dosage forms of drugs, in parameters like sustainability and control of drug release, drug protection, biodegradability, targeting ability and many more. Gemcitabine is a prodrug and is used in various carcinomas. Sodium Alginate and Ethyl Cellulose are used as polymers. The fabrication aims to sustain the drug release which can treat pancreatic, breast, ovarian and lung cancer. Materials and Methods: Microspheres have been made by Ionotropic Gelation method, Sodium alginate, Ethyl cellulose and Calcium chloride. Weighed quantity of drug and polymer were added to sodium alginate solution, which was then added drop wise to Calcium chloride solution under continuous stirring to procure spherical rigid microspheres. These were then subjected to various physicochemical characterizations and surface analysis. Results and Conclusion: Results have shown that by increasing the polymer concentration, entrapment efficiency and drug loading have also increased. Particle size, SEM and micromeritic evaluation have exhibited satisfactory results. The drug release studies depict that most of the batches have showed less than 10% release acid media so it protects the drug from the upper part of GI Tract. These attributes prove that microsphere technology, being a crucial novel drug delivery system can be very effective in reducing dose frequency, dose dumping and better patient compliance.

Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the polymers. The characterization of the new polymer okra showed that it has swelling properties, and in spite of being a hydrophilic polymer, it can be successfully used in pharmaceutical formulation as a good binder.Conclusion: In the present aspect of the study was to evaluate the efficacy of okra gum that has been used as a tablet binder. It is easily available and inexpensive. Okra gum as a binder produces tablet formulations with good physicochemical properties and good candidate for sustained release formulations.