This work introduces briefly an overview and recommendations on worrying SARS-CoV-2 Virus variants, that can be interpreted as the most spread ones till now. They are: Lineage B.1.1.7, Lineage B.1.351, and Lineage P.1. It is also displayed their observations and development in definite locations in Germany as an exemplary version.

Abstract1,2-disubstituted-3-(pyrimidine-2-yl)-2,3-dihydro-1H-1,3-diazepine-4,7-dione were prepared from 2-amino pyrimidine via few steps were found to be useful synthesis for fully unsaturated monocyclic seven-membered heterocyclic ring.In this work the Schiff bases (1-3) was prepared from condensation 2-amino pyimidine with ketones and aldehydes, and then converted into 1,3-oxazepine derivatives(4-6) from maleic anhydride in dry dioxane. Treatment of (4-6) with different amines compounds (hydrazine, 4-amino antipyrine, thiosemicarbazide, and 2-aminothiazole) gave the corresponding 1,3-diazepine derivatives )7-18).. Characterization of 1, 3-diazepine derivatives determined by physical properties and chemical structure confirmed by 1 HNMR and FTIR techniques.