The aim of this study was to investigate the effects of exogenous leptin administration on some stress indicators in streptozotocin (STZ)-induced diabetes rats.In this study wistar albino rats were divided into two main groups (first was 5 day, and second was 10 day), each one subdivided into four groups (5 rat per subgroup): 1. Control, 2. Leptin (10 μg/kg leptin, sc. daily), 3. Diabetes, (induced by single injection of streptoztocin (65 mg/kg bw)) 4. Leptin + diabetes. At the end of the experiments the blood collected by cardiac puncture under anesthesia. Plasma catalase, glutathione, malondialdehyde, and IL-6 levels were measured. Our results showed that diabetes decrease glutathione and catalase levels and increase MDA and IL-6 levels, while leptin treatment reverse these changes.Copy Right, IJAR, 2016,. All rights reserved.

The aim of this study was to investigate the relationship between exogenous leptin and thyroxin on some stress types in rats. In this study 60 male wistar albino rats were divided into two main groups (first was 5 day, and second was 10 day), each one subdivided into six groups (5 rat per subgroup): Control And five treated groups ,which include: Leptin (10 μg/kg leptin, sc. daily), oxidative stress (0.5% H 2 O 2 ), leptin+ oxidative stress, Diabetes, (induced by single injection of streptoztocin (65 mg/kg bw)), and Leptin + diabetes. At the end of the experiments the blood collected by cardiac puncture under anesthesia. Plasma thyroxin and corticosterone were measured. Our results showed that stress decreases thyroxin level and increases corticosterone level, while leptin treatment reverse these changes.

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One of the most frequently worldwide recorded health conditions, is a chronic renal failure (CRF), especially in elderly individuals induced due to renal damage. Kidney damage and therefore, dialysis have several detrimental effects on the body organs and their functions. According to those effects, this study was conducted to recognize the blood lipid profile of the hemodialysis patients in Al-Diwaniyah Province, Iraq. Such determination gives assurance for overall functions of the body organs in order to place proper medical management of those levels if disturbed. From Al-Diwaniyah General Teaching Hospital, Diwaniyah City, Iraq, 68 (50, 33 males and 17 females, hemodialysis CRF (H-CRF) patients and 18, 11 males and 7 females, healthy individuals) samples of blood were collected. For revealing the levels of serum blood lipids of the participants, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were tested using a cholesterol oxidase method for TC and HDL-C, a glycerol kinase method for TG, and the Friedewald formula for LDL-C. The results unveiled significant (p˂0.01) higher TG levels in H-CRF patients than those in healthy individuals. In addition, HDL-C revealed significant (p˂0.01) lower levels in the H-CRF patients than those in healthy people. No significant (p˃0.01) data were observed from the TC and the LDL-C levels in both groups. This work demonstrates the level changes of the TGs and the HDL-C in the serum of the hemodialysis patients which need proper medical intervention for the correction of those levels.