Introduction:To compare the efficacy of two polyherbal Unani formulations in gestational urinary tract infections (GUTIs). Materials and Methods: A prospective, randomized, comparative trial was conducted at Nizamia Tibbia College. Group A (n = 20) received mucilage of Althaea officinalis L. (5 ml) with 2.5 g powder of Sphaeranthus indicus L., Euphorbia hypericifolia L., Tribulus terrestris L., and Sharbat Anar shireen (Punica granatum) 10 ml, whereas Group B (n = 20) received 2.5 g powder of Citrullus vulgaris seeds L., Cucumis melo L. seed, and S. indicus L. orally twice daily after meals for 3 consecutive months. The primary outcome included cured measured as negative urine culture and alleviation of GUTIs symptoms. The secondary outcomes included the absence of pus cell in urine analysis, Apgar score, prevention of complication of GUTIs, and perinatal outcome. The results were analyzed with chi-square, Fisher exact test and student t-test with alpha 0.05. Results: The cure rate in Groups A and B was similar with 50% response. Both groups were equally effective in relieving the GUTIs symptoms (P < 0.001), Apgar score was >7, good perinatal outcome with no preterm labor, and intrauterine growth retardation. No maternal and fetal adverse effects were noted. Conclusion: Both groups were equally effective for the treatment of GUTIs without any maternal and fetal adverse effects.

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