Objective: To determine the mean serum level of C-reactive protein in moderate and severe acne patients visiting to a tertiary care hospital. Setting and Duration Study: This study was conducted at Department of Dermatology, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Pakistan, from November 3, 2020 to May 2, 2021. Materials and Methods: This study was conducted in the Department of dermatology,  Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, from November 3, 2020 to May 2, 2021. An inform consent was also taken prior to the enrolment of patients in the study. The selected participants were referred to the laboratory for hypersensitive-CRP (Hs-CRP) measurement. All the patients of any gender, aged between 16 to 40 years associated with moderate and severe acne duration of more than 3 months were included in this study. Effect modifiers were controlled through stratification of age, gender, duration of acne, and severity of acne (moderate / severe) and these stratified groups were compared by applying independent sample t-test by using P ≤ 0.05 as significant. Results: Mean ± SD of age was 22.7±5.3 years. Mean ± SD of C-reactive protein was 4.15±1.2 (μg/ml). In distribution of gender, out of 56 patients, 30 (53.6%) were male while 26 (46.4%) were female. Out of 56 patients 21 (37.5%) had moderate acne vulgaris while 35 (62.5%) had severe Acne vulgaris. Conclusion: It is to be concluded that mean serum level of C-reactive protein in severe acne patients was high as compared to moderate acne patients. Epidemiological and research data should be expanded by further studies to validate the current findings.

Objective:  To determine the dermoscopic patterns in common pigmented skin lesions. Setting and duration Study: This study was conducted at Dermatology Department, Civil Hospital, Hyderabad, during October 18, 2020 to April 17, 2021. Materials and Methods: After taking approval from hospital ethical committee and written informed consent from 150 patients, all patients with pigmented skin lesions were enrolled. Demographic information were also recorded. Detailed history and thorough dermatological, physical and systemic examination was conducted. Routine investigations and histopathology was taken wherever necessary to aid the clinical diagnosis. Dermoscopic and clinical photographs were taken after informed consent. All dermoscopic findings were studied using handheld pocket dermoscope. In the case of patient having multiple lesions, only a single active lesion was selected for dermoscopy. Results: Age range in this study was from 15 to 60 years with median (IQR) age was17 (15 -60) years and mean duration of disease was 5.67+ 2.14 months. Among the common pigmented skin lesions, 86 (57.4%) had sharp demarcation, 29 (19.3%) had Dots and gobules, 7 (4.5%) had Pseudonetwork, 12 (8%) had Homogenous structure less pigmentation, 78 (52%) had Milia-like cysts and 21 (14%) had Cerebriform pattern. Conclusion: This study shows the high frequency of dermoscopic patterns in common pigmented skin lesions. This concludes that derrmoscopy is a useful and essential technique to clinically manage pigmented skin lesions, and it plays a fundamental role in early identification of pigmented lesions.