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Abstract.A ventilator system provides respiratory support to critically ill patients in the Intensive Care Unit. Increasing complexity in the user interface, features and functionalities of ventilator systems can cause medical errors and cost the life of a patient. Therefore, the usability of ventilator systems is most crucial to ensure patient safety. We have evolved a specialized set of heuristics combined with objectively defined usability indicators for the usability evaluation of touch screen based ventilator systems. Our study presents the heuristic evaluation of three touch screen based ventilator systems manufactured by three different companies. The heuristic evaluation has been performed by four different usability evaluators to ensure the reliability of heuristics proposed in this paper. The specialized set of heuristics linked with user interface components and the objectively defined usability indicators are found more reliable in identifying specific usability problems of ventilator systems.