Abstract Abstract Backgr Backgr Backgr Backgr Background: ound: ound: ound: ound: Hypertriglyceridemia fosters the development of atherosclerosis via several mechanisms and lead to ischemic stroke (IS) through its contribution to thrombogenicity. The association of hypertriglyceridemia with ischemic stroke was evaluated in this study. Methods:Methods: Methods: Methods: Methods: This was a case control study conducted in the Department of Medicine, Dhaka Medical College Hospital and data was collected in a questionnaire from January to June'2013. Patients presented with ischemic stroke, confirmed by CT scan of Head/ MRI of brain from 1 day to 6 months and other than ischemic stroke patients were considered as case and control respectively. Results:Results: Results: Results: Results: The mean age was found 61.0±8.3 years in case group and 60.5±8.1 years in control group. Male were predominant in both groups which was 80 (80.0%) in case group and 84 (84.0%) in control group. More than two third (68.0%) in cases and one fourth (25.0%) in controls patients had hypertension. 12 (12.0%) in cases and 2 (2.0%) in controls patients had heart disease. Normal triglycerides was found 52 (52.0%) in cases and 72 (72.0%) in control. The mean TG was found 179.9±62.8 mg/dl in cases and 148.0±51.9 mg/dl in controls. Desirable cholesterol was found 16 (16.0%) in cases and 25 (25.0%) in controls. The mean cholesterol was found 238.0±4.0 mg/dl in cases and 213.0±42.0 in controls. Optimal LDL was found 12 (12.0%) and 18 (18.0%) in case and control group respectively. Mean LDL was found 167.0±35.2 mg/dl in cases and 141.0±36.1 mg/dl in controls. Low HDL was found 64 (64.0%) in cases and 26 (26.0%) in controls. Mean HDL was found 41.2±10.6 mg/dl in case group and 49.0±8.6 mg/dl in control group.

Background:‘Coronary heart disease (CHD) is now the leading cause of death worldwide; it is on the rise and has become a true pandemic that respects no borders. For the diagnosis of coronary artery disease, the 12 leads electrocardiogram (ECG) is the most readily available noninvasive test by which, in addition of diagnosis, localizing and estimating the size of myocardial ischemia can be determined. Abnormally high QT dispersion has been correlated with risk of arrhythmic death in various cardiac diseases including CAD. An increase in QTd is reported to predict the occurrence of life-threatening ventricular tachyarrhythmias and sudden cardiac death in patients with ischemic heart disease. Materials and Methods: This Cross sectional analytical study was conducted in Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka from January 2013 to December 2013. A total of 100 consecutive patients with angina based on predefined enrollment criteria were included in the study. .All patients were evaluated by history, clinical examination, biochemical analysis, and coronary angiogram (CAG) which was performed during index hospital admission. PCI was done only if the vessel was significantly stenosed.i,e. for LMCA - e”50%, for LAD, LCX and RCA it was e”70% as significant stenosis. Severity of stenosis of the involved vessels were categorized as severe( e”90%) and moderate(<90%). Results: Among the study population 76 (76%) patients were male and 24 (24%) patients were female. The left anterior descending artery (LAD) group comprised 37 patients and there were significant differences between before and after PCI QTc dispersion (90.5±38.9 vs 70.4±39.6 ms, p=0.001). The left circumflex artery (LCX) group was comprised of 6 patients and there were significant differences between before and after PCI QTc dispersion (62.2±41.9 vs 50.2±37.2 ms, p=0.001). The right coronary artery (RCA) group consisted of 18 patients, there being significant differences between before and after PCI QTc dispersion (84.9±40.7 vs 69.1±41.5 ms, p=0.001) Conclusion: PCI reduces QTc dispersion significantly among patients with angina. This QTc dispersion change is not influenced by sex, smoking, beta-blockers, hypertension, diabetes, renal impairment, stable or unstable angina but it depends upon the severity of coronary artery stenosis, involvement of coronary vessel and number of vessels.Reduction of QTc dispersion is a good sign of successful PCI that indicates successful reperfusion which carries an excellent prognostic value of revascularization.Further long term follow up will establish it. University Heart Journal Vol. 16, No. 1, Jan 2020; 33-39

Castleman’s disease is a rare lymphoproliferative disorder. Castleman’s disease is a disease which involves massive non-malignant proliferation of lymphoid tissues that usually presents as mediastinal masses as well as other groups of lymphnodes. That is why, sometimes, confusion may arise whether the lymphadenopathy is benign or malignant. However, some authors describes, histologically and prognostically Castleman’s disease is distinct from malignant lymph-node hyperplasia. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22707 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 124-127

Background: Arrhythmias are often a manifestation of structural heart diseases but may occur in the context of non cardiac diseases even in an otherwise normal heart. It may be supraventricular or ventricular. Among the arrhythmias premature complexes (ventricular & atrial) are most common type of arrhythmia occurs in patients with or without significant heart disease.Objective: In this study, the aim was to find out the aetiological pattern of premature ventricular and atrial complexes and their consequence on morbidity and mortality, demographical pattern of patients with ectopic beats, to find out aetiological factors leading to development of premature complexes, to find out common clinical presentations and to differentiate the PVCs which are more benignMethods: It was a cross sectional study. This study was carried out in the Department of Medicine and Department of Cardiology of Sir Salimullah Medical College and Mitford Hospital, Dhaka from 1st May 2008 to 15th September 2008. A total 50 consecutive patients irrespective of age, sex and occupation having atrial and ventricular premature complexes on ECG attending at OPD and admitted in indoor were included in this study. Results: Among the three types of premature complexes 9 patients with APCs (also includes 2 patients of premature junctional complex) and 41 patients with PVCs were included. The ratio of patients with PVCs and APCs in this study.8.2: 1.8. In this study 41 patients of PVCs were studied. Among them 37 patient that is 90.3% patients had structural heart disease and the commonest cause was IHD (63.4%), 9.7% had HTN with LVH, 7.3% had DCM, 4.87% had HOCM, one patient had myocarditis ( 2.4%) and one had MVP with sick sinus syndrome (2.4%). Among the 9 patients of APC 4 patients that is 44.44% were suffering from COPD with corpulmonale which was the most commonest cause of APCs.Conclusions: Ventricular arrhythmias are more common than atrial arrhythmia and IHD is the single most common cause of arrhythmia. Ectopic beats in patients with otherwise normal hearts are more prominent at rest and disappear with exercise. Treatment is not necessary, unless the patient is highly symptomatic.J MEDICINE July 2015; 16 (2) : 97-102

Introduction: Left main disease (LMD) is related to significant morbidity and mortality. This study was done to evaluate the clinical major adverse cardiovascular event (MACE), including unstable angina, myocardial infarction, heart failure, target vessel revascularization, stroke and death in patients undergoing left main stem stenting without availability of in-site intravascular imaging (IVUS). Methods & Materials: It was a prospective observational study done in National Institute of Cardiovascular Diseases & Hospital (NICVD) from March 2014 to June 2019. Our study included 50 patients who underwent Percutaneous Coronary Intervention for left main disease without use of IVUS. All the patients were followed up for 1 year & 2 years, one patient was lost to follow-up. Outcomes included in MACE were death, myocardial infarction, unstable angina, heart failure, stroke and target vessel revascularization (TVR). Results: Fifty patients (mean age 58.4 ± 4.1 years, 44 male, 06 female) were treated with a mean SYNTAX score of 24.8 ± 2.6. Thirty two (64%) patients had stable angina, 17 (34%) had unstable angina/non ST-elevation myocardial infarction, and 1 (02%) had ST-elevation Myocardial infarction. Among the risk factors, 21(42%) had DM, 33 (66%) were hypertensive, 22 (44%) were smoker, 19 (38%) had dyslipidemia, 09 (18%) had previous h/o MI, 11 (22%) had family h/o CAD & 01 (02%) had previous h/o CVD. Preprocedural LVEF was 49.92± 6.60 % and post procedural 54.84 ± 4.55% which showed significant improvement of LVEF after PCI (p=0.003). Most of the patients presented with LM with SVD (82%). Among all patients, 39 (78%) underwent complete revascularization in compare to 11 (22%) had incomplete revascularization. Thirty eight (76%) patients received a single-stent DES and 12 (24%) received two-stents DES. Among double stent strategy, majority underwent TAP (50%). All access was femoral & No reflow phenomena were found in any of the patients during the procedure. No perioperative mortalities were noted and no urgent coronary bypass graft surgery was required. One patient was lost to follow-up. After 1-year follow-up period, 1 (02%) patients had non-fatal myocardial infarction, 7 (14%) had episodes of unstable angina (UA) and 3 (06%) had heart failure (HF). After 2-years there was no new MI but 09 (18%) had UA & 4 (08%) patients had HF episode in total. TLR was 2 (04%) in first year and 3 (06%) in 2nd year. Total mortality was 1(02%) in first year & 3(06%) in 2nd year. The multivariable analysis showed a good prognosis in patients receiving LM PCI with a total event rate of 28% & mortality 6%. A multivariate regression analysis with risk factors for coronary artery disease as predictive variables showed that high SYNTAX score (p = 0.013), incomplete revascularization (p=0.002) & low post procedural LVEF (p= 0.001) was an independent predictor of MACE. Conclusion: Percutaneous coronary intervention of left main coronary disease without use of IVUS showed good prognosis after 1-year & 2-years follow-up. It would not only save a procedure time for physicians but also prevent a financial burden on patients if they cannot afford intravascular imaging. Bangladesh Heart Journal 2022; 37(1): 1-9